CAJ | 학술논문

目的探讨脑牵拉压(brain retraction pressure,BRP)的测量方法,研究脑牵拉引起脑缺血性损伤的危险性.方法利用电阻应变计制作脑牵拉压的测量装置,对其定标.然后利用此装置,选用新西兰大耳白兔24只,分为对照组和20mmHg组、30mmHg组、40mmHg组,牵拉完毕后,测定局部脑血流量,标本HE染色显微镜观察其损伤.结果该装置具有很高的灵敏性、稳定性和准确性.20 mmHg的BRP牵拉30 min引起轻微脑损伤和脑血流量的降低,30 mmHg的BRP牵拉30 min引起较重脑损伤和脑血流量的显著降低.40 mmHg的BRP牵拉15 nin引起严重脑损伤和脑血流量的极度降低.结论该装置可作为脑牵拉压的测量工具;牵拉时,最好将BRP控制在30mmHg以下.
목적탐토뇌견랍압(brain retraction pressure,BRP)적측량방법,연구뇌견랍인기뇌결혈성손상적위험성.방법이용전조응변계제작뇌견랍압적측량장치,대기정표.연후이용차장치,선용신서란대이백토24지,분위대조조화20mmHg조、30mmHg조、40mmHg조,견랍완필후,측정국부뇌혈류량,표본HE염색현미경관찰기손상.결과해장치구유흔고적령민성、은정성화준학성.20 mmHg적BRP견랍30 min인기경미뇌손상화뇌혈류량적강저,30 mmHg적BRP견랍30 min인기교중뇌손상화뇌혈류량적현저강저.40 mmHg적BRP견랍15 nin인기엄중뇌손상화뇌혈류량적겁도강저.결론해장치가작위뇌견랍압적측량공구;견랍시,최호장BRP공제재30mmHg이하.
[Objective] To investigate the method of measurement of brain retraction pressure (BRP) and observe the risks of brain ischemic injury induced by brain retraction. [Methods] 24 rabbits were randomly divided into control, 20 mmHg (the brain retracted by 20 mmHg pressure), 30 mmHg (by 30 mmHg pressure), 40 mmHg (by 40mmHg pressure) groups. BRP was determined by self-made BRP instrument. The regional cerebral blood flow (rCBF)was measured. The specimen taken from brain tissues retracted by different BRP were observed under microscope.[Results] The mild brain injuries and slight decrease in the rCBF after lasting 30 min retraction were observed in 20mmHg and 30 mmHg groups. The severe brain injuries and significant decrease in the rCBF could be seen after retraction lasting 15 min in 40 mmHg groups. [Conclusions] This instrument can be used as a tool for measuring BRP.The BRP during the brain surgery should not be more than 30 mmHg to avoid brain injuries induced by the retraction.