CAJ | 학술논문

从滑桃树内生真菌Fusarium sp.(1RGa-1b)的发酵代谢产物中分离得到6个一系列的萘醌类色素化合物,通过波谱分析将其结构鉴定为:3-methyl ether-fusarubin(1), anhydrofusarubin (2),2-acetonyl-3-methyl-5-hydro-gen-7-methoxy-naphthazarin (3), 2-acetonyl-3-methyl-7-methoxy-8-hydrogen-naphthazarin (4), 2-acetonyl-3-methyl-7-methoxy-naphthazarin($) ,2-isopropand-3-methyl-7-methoxy-naphthazarin(6).利用纸片扩散法对这些化合物的抗细菌及抗真菌活性进行了初步测试,实验结果表明:化合物3和4具有弱的抗金黄色葡萄球菌的活性.
종활도수내생진균Fusarium sp.(1RGa-1b)적발효대사산물중분리득도6개일계렬적내곤류색소화합물,통과파보분석장기결구감정위:3-methyl ether-fusarubin(1), anhydrofusarubin (2),2-acetonyl-3-methyl-5-hydro-gen-7-methoxy-naphthazarin (3), 2-acetonyl-3-methyl-7-methoxy-8-hydrogen-naphthazarin (4), 2-acetonyl-3-methyl-7-methoxy-naphthazarin($) ,2-isopropand-3-methyl-7-methoxy-naphthazarin(6).이용지편확산법대저사화합물적항세균급항진균활성진행료초보측시,실험결과표명:화합물3화4구유약적항금황색포도구균적활성.
An isolate of Fusarium sp. 1RGa-1 b was obtained from the root of Trewia nudiflora, a plant of Euphorbiaceae family. The ethyl acetate extraction part of the crude extract from culture of this fungus afforded six naphthaquinones. The structures of these compounds were identified as 3-methy ether-fusarubin(1), anhydrofusarubin(2) ,2-acetonyl-3-meth-yl-5-hydrogen-7-methoxy-naphthazarin (3), 2-acetonyl-3-methyl-7-ethoxy-8-hydrogen-naphthazarin (4) , 2-acetonyl-3-methyl-7-methoxy-naphthazarin(5), 2-isopropanol-3-methyl-7-methoxy-naphthazarin (6), based on analysis of spectro-scopic data. Antifungal and antibacterial assay tests revealed that 3 and 4 showed in vitro weak antibacterial activity a-gainst Staphylococcus aureus.