CAJ | 학술논문

背景:目前尚未见应用脐带间充质干细胞治疗脊髓小脑性共济失调的报道.目的:观察脐带间充质干细胞治疗脊髓小脑性共济失调的临床效果.方法:选择2010-09/12解放军455医院干细胞移植中心收治的12例脊髓小脑共济失调患者,给予脐带间充质干细胞鞘内注射,每次107个细胞,1次/周,4次为1个疗程.结果与结论:患者治疗后1个月与治疗前比较国际合作共济失调评分量表评分及日常生活量表评分均明显降低(P < 0.05),提示患者的神经功能显著改善,总有效率为16.7%.说明脐带间充质干细胞鞘内注射治疗可以在一定程度上改善脊髓小脑性共济失调患者的临床症状,提高患者生活质量.
배경:목전상미견응용제대간충질간세포치료척수소뇌성공제실조적보도.목적:관찰제대간충질간세포치료척수소뇌성공제실조적림상효과.방법:선택2010-09/12해방군455의원간세포이식중심수치적12례척수소뇌공제실조환자,급여제대간충질간세포초내주사,매차107개세포,1차/주,4차위1개료정.결과여결론:환자치료후1개월여치료전비교국제합작공제실조평분량표평분급일상생활량표평분균명현강저(P < 0.05),제시환자적신경공능현저개선,총유효솔위16.7%.설명제대간충질간세포초내주사치료가이재일정정도상개선척수소뇌성공제실조환자적림상증상,제고환자생활질량.
BACKGROUND: There is no study addressing transplantation of umbilical cord mesenchymal stem cells for the treatment of spinocerebellar ataxia.OBJECTIVE: To study the clinical effect of human umbilical cord stem cells transplantation in the treatment of autosomal dominant spinocerebellar ataxias. METHODS: Spinocerebellar ataxias patients selected from Stem Transplantation Center of the 455 Hospital of Chinese PLA were treated with umbilical cord mesenchymal stem cells transplantation via intrathecal injection. The number of umbilical cord mesenchymal stem cells was 107 per transplantation, once per week, for 4 weeks.RESULTS AND CONCLUSION: Both the total score of the International Cooperative Ataxia Rating Scale and Activities of Daily Living score were significantly decreased at 1 month after transplantation compared with before treatment (P < 0.05). The nerve function was significantly improved and the total effective rate was up to 16.7%. Experimental findings indicate that, transplantation of umbilical cord mesenchymal stem cells via intrathecal injection is a feasible and effective treatment to ameliorate the clinical efficacy of spinocerebellar ataxias patients and improve their quality of life.