CAJ | 학술논문

Toll样受体(TLRs)的发现,使人们对HBV感染免疫有了新的认识.目前研究认为,TLRs除了介导抗HBV感染天然免疫外,还能促进树突状细胞(DC)成熟,调节Th1/Th2型免疫,参与抗HBV特异性免疫,同时,HBV也影响某些TLRs的表达,这可能是HBV感染慢性化的原因之一.进一步明确TLRs在HBV感染免疫中的作用,可为HBV感染的治疗提供一个新的切入点.
Toll양수체(TLRs)적발현,사인문대HBV감염면역유료신적인식.목전연구인위,TLRs제료개도항HBV감염천연면역외,환능촉진수돌상세포(DC)성숙,조절Th1/Th2형면역,삼여항HBV특이성면역,동시,HBV야영향모사TLRs적표체,저가능시HBV감염만성화적원인지일.진일보명학TLRs재HBV감염면역중적작용,가위HBV감염적치료제공일개신적절입점.
The discovery of Toll-like receptors (TLRs) has helped people to gain a new understanding on the anti-HBV immunity. Recent studies showed that TLRs not only mediated the anti-HBV innate immunity, but also participated in the anti-HBV adaptive immunity by promoting the maturation of DCs and regulatingTH1/TH2 immunity. But it is still doubtful it HBV affect the expression of TLRs and is one of the factors that cause the chronic HBV infection. Therefore, it is necessary to clarify the role of TLRs in HBV infection further in order to gain new insights for the prevention and treatment of HBV infection.