CAJ | 학술논문

脂联素是由脂肪细胞分泌的一种内源性生物活性多肽.多项研究结果表明,脂联素具有抗炎、抗动脉粥样硬化、抑制新生血管、抗氧化应激及调节能量代谢等心血管保护作用.流行病学调查亦显示:在一些肥胖相关疾病的患者体内,脂联素水平的降低与心血管疾病风险增加相关.脂联素的作用机制复杂,与多种信号转导通路有关.脂联素有望为糖尿病心血管疾病的治疗提供新思路.
지련소시유지방세포분비적일충내원성생물활성다태.다항연구결과표명,지련소구유항염、항동맥죽양경화、억제신생혈관、항양화응격급조절능량대사등심혈관보호작용.류행병학조사역현시:재일사비반상관질병적환자체내,지련소수평적강저여심혈관질병풍험증가상관.지련소적작용궤제복잡,여다충신호전도통로유관.지련소유망위당뇨병심혈관질병적치료제공신사로.
Adiponectin is an endogenous biologically active peptides secreted by adipocytes.Several studies indicate that adiponectin has many protective effects on cardiovascular system,such as anti-inflammatory,antiatherogenic,inhibition of angiogenesis,antioxidant stress,regulation of energy metabolism,etc.Epidemiological studies have also shown that reduced level of adiponectin is correlate with increased risk of cardiovascular disease in patients with obesity related diseases.The mechanisms of adiponectin is complex,and it is connected with various signaling cascades.Adiponectin may provide a new therapy of cardiovascular disease in patients with diabetes.