中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
28期
23-25
,共3页
红斑狼疮,系统性%高血压,肺性%雷诺病
紅斑狼瘡,繫統性%高血壓,肺性%雷諾病
홍반랑창,계통성%고혈압,폐성%뢰낙병
Lupus erythematosus,systemic%Hypertension,pulmonary%Raynaud disease
目的 探讨雷诺现象在系统性红斑狼疮(SLE)中的意义.方法 对112例SLE患者的临床资料进行回顾性分析,比较有和无雷诺现象患者在临床表现、实验室检查等方面的异同.结果 有雷诺现象患者肺动脉高压、肺间质病变、心包炎、乏力、肺栓塞、深静脉血栓形成的发生率明显高于无雷诺现象患者[ 89.3％( 25/28)比2.4％( 2/84)、57.1％(16/28)比16.7％( 14/84)、75.0％(21/28)比39.3％(33/84)、67.9％( 19/28)比33.3％(28/84)、21.4％(6/28)比4.8％(4/84)、14.3％(14/28)比1.2％(1/84) ](P＜ 0.05)；抗心磷脂抗体、抗RNP抗体、抗Sm抗体、狼疮抗凝物试验阳性率明显高于无雷诺现象患者[46.4％(13/28)比9.5％ (8/84)、75.0％(21/28)比33.3％(28/84)、57.1％(16/28)比23.8％(20/84)、17.9％(5/28)比2.4％(2/84)] (P＜ 0.05),白细胞计数减少发生率明显低于无雷诺现象患者[7.1％(2/28)比45.2％(38/84) ](P=0.001).结论 SLE出现雷诺现象患者易发生心、肺及血管病变,尤其肺动脉高压、肺间质病变、心包炎、肺栓塞等,且抗心磷脂抗体、抗RNP抗体、抗Sm抗体、狼疮抗凝物试验阳性率高于无雷诺现象患者.
目的 探討雷諾現象在繫統性紅斑狼瘡(SLE)中的意義.方法 對112例SLE患者的臨床資料進行迴顧性分析,比較有和無雷諾現象患者在臨床錶現、實驗室檢查等方麵的異同.結果 有雷諾現象患者肺動脈高壓、肺間質病變、心包炎、乏力、肺栓塞、深靜脈血栓形成的髮生率明顯高于無雷諾現象患者[ 89.3％( 25/28)比2.4％( 2/84)、57.1％(16/28)比16.7％( 14/84)、75.0％(21/28)比39.3％(33/84)、67.9％( 19/28)比33.3％(28/84)、21.4％(6/28)比4.8％(4/84)、14.3％(14/28)比1.2％(1/84) ](P＜ 0.05)；抗心燐脂抗體、抗RNP抗體、抗Sm抗體、狼瘡抗凝物試驗暘性率明顯高于無雷諾現象患者[46.4％(13/28)比9.5％ (8/84)、75.0％(21/28)比33.3％(28/84)、57.1％(16/28)比23.8％(20/84)、17.9％(5/28)比2.4％(2/84)] (P＜ 0.05),白細胞計數減少髮生率明顯低于無雷諾現象患者[7.1％(2/28)比45.2％(38/84) ](P=0.001).結論 SLE齣現雷諾現象患者易髮生心、肺及血管病變,尤其肺動脈高壓、肺間質病變、心包炎、肺栓塞等,且抗心燐脂抗體、抗RNP抗體、抗Sm抗體、狼瘡抗凝物試驗暘性率高于無雷諾現象患者.
목적 탐토뢰낙현상재계통성홍반랑창(SLE)중적의의.방법 대112례SLE환자적림상자료진행회고성분석,비교유화무뢰낙현상환자재림상표현、실험실검사등방면적이동.결과 유뢰낙현상환자폐동맥고압、폐간질병변、심포염、핍력、폐전새、심정맥혈전형성적발생솔명현고우무뢰낙현상환자[ 89.3％( 25/28)비2.4％( 2/84)、57.1％(16/28)비16.7％( 14/84)、75.0％(21/28)비39.3％(33/84)、67.9％( 19/28)비33.3％(28/84)、21.4％(6/28)비4.8％(4/84)、14.3％(14/28)비1.2％(1/84) ](P＜ 0.05)；항심린지항체、항RNP항체、항Sm항체、랑창항응물시험양성솔명현고우무뢰낙현상환자[46.4％(13/28)비9.5％ (8/84)、75.0％(21/28)비33.3％(28/84)、57.1％(16/28)비23.8％(20/84)、17.9％(5/28)비2.4％(2/84)] (P＜ 0.05),백세포계수감소발생솔명현저우무뢰낙현상환자[7.1％(2/28)비45.2％(38/84) ](P=0.001).결론 SLE출현뢰낙현상환자역발생심、폐급혈관병변,우기폐동맥고압、폐간질병변、심포염、폐전새등,차항심린지항체、항RNP항체、항Sm항체、랑창항응물시험양성솔고우무뢰낙현상환자.
Objective To study the clinical significance of Raynaud phenomenon (RP) in systemic lupus erythematosus(SLE).Methods One hundred and twelve cases with SLE were divided into two groups according to the condition of RP and were analyzed retrospectively.The similarities and differences were investigated in system injury and laboratory examination in two groups.Results The occurrence rates of pulmonary arterial hypertension (PAH),interstitial lung disease (ILD),pericarditis,fatigue,pulmonary embolism (PE) and deep venous thrombosis (DVT) in patients with RP were higher than those in patients without RP [89.3％(25/28) vs.2.4％(2/84),57.1％(16/28) vs.16.7％(14/84),75.0％(21/28) vs.39.3％ (33/84),67.9％(19/28) vs.33.3％(28/84),21.4％(6/28) vs.4.8％(4/84),14.3％(14/28) vs.1.2％(1/84) ](P ＜ 0.05 ).The positive rates of anti-cardiolipin (ACL) antibody,anti-RNP antibody,anti-Sm antibody and LA in patients with RP were higher than those in patients without RP [46.4％(13/28) vs.9.5％(8/84),75.0％(21/28) vs.33.3％(28/84),57.1％(16/28) vs.23.8％(20/84),17.9％(5/28) vs.2.4％(2/84)] (P ＜0.05),while leucopenia in patients with RP was lower than that in patients without RP [7.1％(2/28) vs.45.2％ (38/84)] (P =0.001).Conclusion Heart,lung and vascular lesions such as PAH,ILD,pericarditis,PE and so on are easier to occur in SLE with RP,furthermore the positive rates of ACL,anti-RNP antibody,anti-Sm antibody,and LA are higher than those without RP.
