CAJ | 학술논문

放化综合治疗是局部晚期非小细胞肺癌(NSCLC)的基本治疗策略.近期研究表明同期放化疗在生存率等方面优于序贯治疗,已成为局部晚期NSCLC的标准治疗模式,但是尚无具体放化结合模式指导临床治疗.为了进一步提高治疗疗效,目前临床研究主要集中于以下几个方面:同期放化治疗加入诱导或巩固化疗、同期放化疗中放疗分割方式的改变、同期放化疗中化疗方式及方案的选择、同期放化疗加入分子靶向治疗.
방화종합치료시국부만기비소세포폐암(NSCLC)적기본치료책략.근기연구표명동기방화료재생존솔등방면우우서관치료,이성위국부만기NSCLC적표준치료모식,단시상무구체방화결합모식지도림상치료.위료진일보제고치료료효,목전림상연구주요집중우이하궤개방면:동기방화치료가입유도혹공고화료、동기방화료중방료분할방식적개변、동기방화료중화료방식급방안적선택、동기방화료가입분자파향치료.
Combination of chemotherapy and radiotherapy is foundational treatment approach for locally advanced non- small cell lung cancer (NSCLC) patients. Concomitant chemo-radiotherapy have been demons-trated to be better than sequential chemoradiotherapy in survival rate, and it is considered as a standard approach in patients with locally advanced NSCLC. However, the chemo-radiotherapy regimens remain uncert-ain. The main clinical researches aiming at improving the survival rate of locally advanced NSCLC patients are the addition of induction or consolidation, the alteration of radiation fractionation, the alteration of chemo schema and the inte- gration of molecularly targeted therapies combining with concurrent chemo-radiotherapy.