CAJ | 학술논문

目的探讨超声探测甲状腺结节钙化对甲状腺癌的诊断价值.方法回顾性分析我院3924例甲状腺疾病患者的超声资料和病理结果,探讨钙化、微小钙化、粗大钙化和边缘环状钙化与甲状腺癌的关系,单发结节伴钙化和多发结节伴钙化与甲状腺癌的关系以及不同年龄组钙化与甲状腺癌的关系. 结果甲状腺良性疾病钙化和微小钙化的发生率分别为32.05％和6.50％,甲状腺癌则为80.07％和51.53％,甲状腺癌钙化和微小钙化的发生率高于良性疾病(P＜0.01)；单发结节和多发结节伴钙化的恶性率分别为53.31％和22.16％,伴微小钙化的恶性率则分别为74.12％和47.92％,单发结节伴钙化和伴微小钙化的恶性率均要高于多发结节,差异有统计学意义(P＜0.01)；＜70岁患者钙化的恶性率随年龄增加逐渐下降(P＜0.05)；微小钙化的恶性率在44岁及以下年龄组＞44岁以上年龄组(P＜0.01).结论钙化和微小钙化是甲状腺癌的高危因素,单发结节和年轻患者的钙化和微小钙化的恶性率更高.
목적 탐토초성탐측갑상선결절개화대갑상선암적진단개치.방법 회고성분석아원3924례갑상선질병환자적초성자료화병리결과,탐토개화、미소개화、조대개화화변연배상개화여갑상선암적관계,단발결절반개화화다발결절반개화여갑상선암적관계이급불동년령조개화여갑상선암적관계. 결과 갑상선량성질병개화화미소개화적발생솔분별위32.05％화6.50％,갑상선암칙위80.07％화51.53％,갑상선암개화화미소개화적발생솔고우량성질병(P＜0.01)；단발결절화다발결절반개화적악성솔분별위53.31％화22.16％,반미소개화적악성솔칙분별위74.12％화47.92％,단발결절반개화화반미소개화적악성솔균요고우다발결절,차이유통계학의의(P＜0.01)；＜70세환자개화적악성솔수년령증가축점하강(P＜0.05)；미소개화적악성솔재44세급이하년령조＞44세이상년령조(P＜0.01).결론 개화화미소개화시갑상선암적고위인소,단발결절화년경환자적개화화미소개화적악성솔경고.
Objective To investigate the clinical value of sonographic detection for calcification in diagnosis of thyroid carcinoma. Methods Clinical data of 3924 thyroid disease patients examined by ultrasonography and pathology at First Hospital of China Medical University were retrospectively reviewed to investigate the relationship between calcification, microcalcification, macrocalcification and peripheral calcification with thyroid carcinoma,the relationship between solitary nodule with calcification and multiple nodules with calcification with thyroid carcinoma and the relationship between calcification with thyroid carcinoma in different age groups. Results The incidences of calcification,microcalcification in malignant and benign thyroid patients were 32.05％,6.50％ and 80.07％,51.53％,the incidences of calcification and microcalcification were significantly higher in malignant group than in benign group (P ＜ 0.01 ).The incidence of carcinoma in solitary nodules with calcification was 53.33％ while it was 22.2％ in multiple nodule group,the incidence of carcinoma in solitary nodules with calcification was significantly higher than that in multiple nodules (P ＜ 0.01 ).The incidence of carcinoma in solitary nodules with microcalcification was 74.1％ while in multiple nodule group it was 47.9％,the incidence of carcinoma in solitary nodules with microcalcification was significantly higher than that in multiple nodules ( P ＜ 0.01 ).The incidence of carcinoma younger than 70 years of age with caicification in different age groups was significantly different (P ＜ 0.05).In 40 and younger age group,the incidence of carcinoma with microcaicification was higher than that in over 44 years group (P ＜ 0.01 ). Conclusions Calcification or microcalcification is considered to be a risk factor of thyroid carcinoma.Solitary nodules with calcification or microcalcification found in younger patients were more likely to coexist with thyroid carcinoma.