CAJ | 학술논문

目的探讨围术期使用磷酸肌酸钠在室间隔缺损伴重度肺动脉高压(室缺肺高压)手术患儿血流动力学及心功能的影响.方法根据随机数字表选择2008年1月至2009年6月符合重度肺动脉高压诊断标准的100例室间隔缺损患儿,分为对照组50例,术前常规给予强心、利尿、血管活性药物等;治疗组50例,术上除常规给予前述治疗外,给予注射用磷酸肌酸钠2 g,静脉滴注3 d.结果 2组术前心率、桡动脉收缩压(sAP)、中心静脉压(CVP)、左心室射血分数(EF)、左心室长轴缩短率(FS)、肺动脉压力及氧分压比较差异无统计学意义(P＞0.05).手术后5 d 2组上述各项指标分别与术前相比差异有统计学意义(P＜0.05),治疗较对照组手术患儿血流动力学及心脏功能明显改善,2组术后拔管时间及监护室时间差异有统计学意义[(39±13)h vs (54 ±12)h;(122 ±46)h vs(187 ±62)h](P＜0.01).结论磷酸肌酸钠作为细胞中能量转移的载体,针对室缺肺高压患儿,进行围手术期治疗,术后血流动力学及心功能明显改善,术后恢复时间明显缩短.
목적 탐토위술기사용린산기산납재실간격결손반중도폐동맥고압(실결폐고압)수술환인혈류동역학급심공능적영향.방법 근거수궤수자표선택2008년1월지2009년6월부합중도폐동맥고압진단표준적100례실간격결손환인,분위대조조50례,술전상규급여강심、이뇨、혈관활성약물등;치료조50례,술상제상규급여전술치료외,급여주사용린산기산납2 g,정맥적주3 d.결과 2조술전심솔、뇨동맥수축압(sAP)、중심정맥압(CVP)、좌심실사혈분수(EF)、좌심실장축축단솔(FS)、폐동맥압력급양분압비교차이무통계학의의(P＞0.05).수술후5 d 2조상술각항지표분별여술전상비차이유통계학의의(P＜0.05),치료교대조조수술환인혈류동역학급심장공능명현개선,2조술후발관시간급감호실시간차이유통계학의의[(39±13)h vs (54 ±12)h;(122 ±46)h vs(187 ±62)h](P＜0.01).결론 린산기산납작위세포중능량전이적재체,침대실결폐고압환인,진행위수술기치료,술후혈류동역학급심공능명현개선,술후회복시간명현축단.
Objective To study the effective evaluation of creatine phosphate sodium in patients ventricular septal defect with severe pulmonary hypertension.Methods Totally 64 patients of ventricular septal defect with severe pulmonary hypertension were randomly divided into two groups:experimental group(routine treatment plus Creatine Phosphate Sodium) and control group (routine treatment).Results Indexes of hemodynamics and cardiac function of experimental group were significantly improved (P ＜0.05).Time of intensive care unit (ICU) and extraction of tracheal intubation of experimental group was shorter (P = 0.011).Conclusions Creatine phosphate sodium can reduce the time of cure and improve the homodynamic and cardiac function in patients of ventricular septal defect with severe pulmonary hypertension after operation.