中华航海医学与高气压医学杂志
中華航海醫學與高氣壓醫學雜誌
중화항해의학여고기압의학잡지
CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
2011年
4期
205-207
,共3页
高压氧%食管癌%survivin蛋白%放射治疗
高壓氧%食管癌%survivin蛋白%放射治療
고압양%식관암%survivin단백%방사치료
Hyperbaric oxygen%Esophageal carcinoma%Survivin protein%Radiation therapy
目的 探讨食管癌患者survivin蛋白的表达及高压氧联合放射治疗对survivin蛋白表达的影响。方法 应用免疫组织化学SP法检测65例食管癌患者及20名正常人食管黏膜组织survivin蛋白表达情况。结果 食管癌患者survivin蛋白表达率为70.8％ (46/65)，正常人食管黏膜组织中表达率为5％ (1/20)。survivin蛋白的表达与肿瘤的淋巴转移关系密切，有淋巴转移的患者survivin蛋白阳性率与无淋巴转移的患者比较差异有统计学意义(P＜0.05)。食道癌患者高压氧联合放射治疗与单纯放射治疗比较，临床症状有所改善，survivin蛋白阳性表达率降低，差异有统计学意义(P＜0.05)。结论 survivin蛋白阳性表达与食管癌的生长及转移有关，参与食管癌的发生发展。高压氧与放射治疗联合应用可提高临床疗效。
目的 探討食管癌患者survivin蛋白的錶達及高壓氧聯閤放射治療對survivin蛋白錶達的影響。方法 應用免疫組織化學SP法檢測65例食管癌患者及20名正常人食管黏膜組織survivin蛋白錶達情況。結果 食管癌患者survivin蛋白錶達率為70.8％ (46/65)，正常人食管黏膜組織中錶達率為5％ (1/20)。survivin蛋白的錶達與腫瘤的淋巴轉移關繫密切，有淋巴轉移的患者survivin蛋白暘性率與無淋巴轉移的患者比較差異有統計學意義(P＜0.05)。食道癌患者高壓氧聯閤放射治療與單純放射治療比較，臨床癥狀有所改善，survivin蛋白暘性錶達率降低，差異有統計學意義(P＜0.05)。結論 survivin蛋白暘性錶達與食管癌的生長及轉移有關，參與食管癌的髮生髮展。高壓氧與放射治療聯閤應用可提高臨床療效。
목적 탐토식관암환자survivin단백적표체급고압양연합방사치료대survivin단백표체적영향。방법 응용면역조직화학SP법검측65례식관암환자급20명정상인식관점막조직survivin단백표체정황。결과 식관암환자survivin단백표체솔위70.8％ (46/65)，정상인식관점막조직중표체솔위5％ (1/20)。survivin단백적표체여종류적림파전이관계밀절，유림파전이적환자survivin단백양성솔여무림파전이적환자비교차이유통계학의의(P＜0.05)。식도암환자고압양연합방사치료여단순방사치료비교，림상증상유소개선，survivin단백양성표체솔강저，차이유통계학의의(P＜0.05)。결론 survivin단백양성표체여식관암적생장급전이유관，삼여식관암적발생발전。고압양여방사치료연합응용가제고림상료효。
Objective To study the effect of hyperbaric oxygen (HBO) coupled with radiation therapy on the expression of survivin in patients with esophageal carcinoma(EC). Methods The expression of survivin was measured by immunohistochemical (SP) method in 65 cases of EC, and in 39 people with normal esophageal mucosa. Results The expression rate of survivin was 70. 8％ (46/65)in patients with EC, while the expression rate of survivin was only 0. 05％ (1/20) in the normal mucosa tissue. The expression of survivin was closely correlated with lymph node metastasis (LNM). The positive rate of survivin expression in LNM patients was significantly higher than that of the patients without LNM ( P ＜ 0. 05 ). Clinical symptoms in the patients treated with HBO coupled with radiotherapy improved considerably, when compared with those of the patients treated only with radiotherapy. The positive rate of survivin decreased with statistical significance (P ＜0. 05 ). Conclusions The high expression rate of survivin was closely correlated with the growth and metastasis of EC. HBO coupled with radiotherapy could enhance the therapeutic efficacy of the disease.
