中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2010年
4期
259-263
,共5页
曹园园%马建华%李倩%叶新华%俞晓芳%高燕勤%陆莹%杜文聪%成金罗%周玲
曹園園%馬建華%李倩%葉新華%俞曉芳%高燕勤%陸瑩%杜文聰%成金囉%週玲
조완완%마건화%리천%협신화%유효방%고연근%륙형%두문총%성금라%주령
PPARγ基因%糖尿病,2型%单核苷酸多态性%病例对照研究
PPARγ基因%糖尿病,2型%單覈苷痠多態性%病例對照研究
PPARγ기인%당뇨병,2형%단핵감산다태성%병례대조연구
PPARγ gene%T2DM% SNP% Casecontrol study
目的 探讨江苏省汉族人群PPARγ基因外显子区两个单核甘酸多态性(rs1801282,rs3856806)与2型糖尿病(T2DM)的关系.方法 采用病例对照研究选取新发T2DM 296例,年龄、性别频数匹配的健康对照477名,用PCR-RFLP方法进行两位点多态性检测.结果 PPARγ基因rs3856806位点多态性在病例组与对照组的分布差异有统计学意义(P＜0.05).与携带CC型相比较,携带CT/TT型者患T2DM风险降低.分层分析发现在女性、>50岁、高血压或体重正常群体中,携带CT/TT型者较CC型者患T2DM风险降低[OR值分别为0.33 (95%CI: 0.14,0.76),0.45 (95%CI: 0.23,0.88)、0.59 (95%CI: 0.36,0.95),0.34 (95%CI: 0.13,0.94)].rs1801282位点多态性在病例组和对照组中的分布差异无统计学意义(P＞0.05),但分层分析发现,携带CG(Pro/Ala)型肥胖者较CC型者患T2DM发病风险降低[OR(95%CI)=0.30(0.09,0.90)].结论 PPARγ基因多态性改变可能与江苏汉族人群T2DM遗传易感性有关.
目的 探討江囌省漢族人群PPARγ基因外顯子區兩箇單覈甘痠多態性(rs1801282,rs3856806)與2型糖尿病(T2DM)的關繫.方法 採用病例對照研究選取新髮T2DM 296例,年齡、性彆頻數匹配的健康對照477名,用PCR-RFLP方法進行兩位點多態性檢測.結果 PPARγ基因rs3856806位點多態性在病例組與對照組的分佈差異有統計學意義(P＜0.05).與攜帶CC型相比較,攜帶CT/TT型者患T2DM風險降低.分層分析髮現在女性、>50歲、高血壓或體重正常群體中,攜帶CT/TT型者較CC型者患T2DM風險降低[OR值分彆為0.33 (95%CI: 0.14,0.76),0.45 (95%CI: 0.23,0.88)、0.59 (95%CI: 0.36,0.95),0.34 (95%CI: 0.13,0.94)].rs1801282位點多態性在病例組和對照組中的分佈差異無統計學意義(P＞0.05),但分層分析髮現,攜帶CG(Pro/Ala)型肥胖者較CC型者患T2DM髮病風險降低[OR(95%CI)=0.30(0.09,0.90)].結論 PPARγ基因多態性改變可能與江囌漢族人群T2DM遺傳易感性有關.
목적 탐토강소성한족인군PPARγ기인외현자구량개단핵감산다태성(rs1801282,rs3856806)여2형당뇨병(T2DM)적관계.방법 채용병례대조연구선취신발T2DM 296례,년령、성별빈수필배적건강대조477명,용PCR-RFLP방법진행량위점다태성검측.결과 PPARγ기인rs3856806위점다태성재병례조여대조조적분포차이유통계학의의(P＜0.05).여휴대CC형상비교,휴대CT/TT형자환T2DM풍험강저.분층분석발현재녀성、>50세、고혈압혹체중정상군체중,휴대CT/TT형자교CC형자환T2DM풍험강저[OR치분별위0.33 (95%CI: 0.14,0.76),0.45 (95%CI: 0.23,0.88)、0.59 (95%CI: 0.36,0.95),0.34 (95%CI: 0.13,0.94)].rs1801282위점다태성재병례조화대조조중적분포차이무통계학의의(P＞0.05),단분층분석발현,휴대CG(Pro/Ala)형비반자교CC형자환T2DM발병풍험강저[OR(95%CI)=0.30(0.09,0.90)].결론 PPARγ기인다태성개변가능여강소한족인군T2DM유전역감성유관.
Objective To explore the relationship between two functional polymorphisms in exons of the PPARγ gene and the susceptibility to T2DM. MethodsPCRRFLP was performed to test the genotypes in 296 newlydiagnosed T2DM cases and 477 controls matched for age and sex. Results The rs3856806 polymorphism of PPARγ gene showed a significant difference between T2DM cases and controls. Compared with CC genotype, those carrying CT/TT genotype had a lower T2DM risk. In the stratified analysis, compared with CC genotype, those carrying CT/TT genotype had a significantly reduced risk in female，the elders (aged above 50 years)，hypertensive subjects and normal weight individuals with OR value of 0.33(95%CI: 0.14, 0.76), 0.45(95%CI: 0.23, 0.88), 059(95%CI: 0.36, 0.95) and 0.34(95%CI: 0.13, 0.94), respectively. There was no significant difference in genotype frequency of rs1801282 polymorphism between T2DM patients and controls. However, the obese individuals carrying CG(Pro/Ala) genotypes had a lower T2DM risk. Conclusions The polymorphisms of PPARγ gene might play a role in the susceptibility of T2DM in Han population of Jiangsu.
