中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
16期
7-9
,共3页
脑梗塞%促肾上腺皮质激素%氢化可的松
腦梗塞%促腎上腺皮質激素%氫化可的鬆
뇌경새%촉신상선피질격소%경화가적송
Brain infarction%Adrenocorticotropic hormone%Hydrocortisone
目的 探讨不同时点血浆促肾上腺皮质激素(ACTH)和皮质醇变化在急性脑梗死患者中的临床意义.方法 采用电化学发光法检测62例急性脑梗死患者(脑梗死组)和60例健康体检者(健康对照组)8:00、16:00、24:00的血浆ACTH和皮质醇水平,并进行比较.结果 急性脑梗死组8:00、16:00、24:00血浆ACTH水平高于健康对照组[(20.5±4.2)pmol/L 比(10.4±2.6)pmol/L,(18.9±4.9)pmol/L 比(8.5±21)pmol/L,(181±3 8)pmol/L比(7.1±2.4)pmol/L],皮质醇水平也明显高于健康对照组[(542±76)nmol/L 比(469±65)nmol/L,(528±43)nmol/L比(341±33)nmol/L,(499±32)nmol/L比(196±27)nmol/L],差异均有统计学意义(P＜0.05).随病情的加重,急性脑梗死患者各时点血浆ACTH和皮质醇水平显著升高(P＜0.05);预后好者不同时点血浆ACTH和皮质醇水平均明显低于预后差者(P＜0.05).结论 不同时点血浆ACTH和皮质醇的检测,对判断急性脑梗死患者的病情及预后具有重要的临床意义.
目的 探討不同時點血漿促腎上腺皮質激素(ACTH)和皮質醇變化在急性腦梗死患者中的臨床意義.方法 採用電化學髮光法檢測62例急性腦梗死患者(腦梗死組)和60例健康體檢者(健康對照組)8:00、16:00、24:00的血漿ACTH和皮質醇水平,併進行比較.結果 急性腦梗死組8:00、16:00、24:00血漿ACTH水平高于健康對照組[(20.5±4.2)pmol/L 比(10.4±2.6)pmol/L,(18.9±4.9)pmol/L 比(8.5±21)pmol/L,(181±3 8)pmol/L比(7.1±2.4)pmol/L],皮質醇水平也明顯高于健康對照組[(542±76)nmol/L 比(469±65)nmol/L,(528±43)nmol/L比(341±33)nmol/L,(499±32)nmol/L比(196±27)nmol/L],差異均有統計學意義(P＜0.05).隨病情的加重,急性腦梗死患者各時點血漿ACTH和皮質醇水平顯著升高(P＜0.05);預後好者不同時點血漿ACTH和皮質醇水平均明顯低于預後差者(P＜0.05).結論 不同時點血漿ACTH和皮質醇的檢測,對判斷急性腦梗死患者的病情及預後具有重要的臨床意義.
목적 탐토불동시점혈장촉신상선피질격소(ACTH)화피질순변화재급성뇌경사환자중적림상의의.방법 채용전화학발광법검측62례급성뇌경사환자(뇌경사조)화60례건강체검자(건강대조조)8:00、16:00、24:00적혈장ACTH화피질순수평,병진행비교.결과 급성뇌경사조8:00、16:00、24:00혈장ACTH수평고우건강대조조[(20.5±4.2)pmol/L 비(10.4±2.6)pmol/L,(18.9±4.9)pmol/L 비(8.5±21)pmol/L,(181±3 8)pmol/L비(7.1±2.4)pmol/L],피질순수평야명현고우건강대조조[(542±76)nmol/L 비(469±65)nmol/L,(528±43)nmol/L비(341±33)nmol/L,(499±32)nmol/L비(196±27)nmol/L],차이균유통계학의의(P＜0.05).수병정적가중,급성뇌경사환자각시점혈장ACTH화피질순수평현저승고(P＜0.05);예후호자불동시점혈장ACTH화피질순수평균명현저우예후차자(P＜0.05).결론 불동시점혈장ACTH화피질순적검측,대판단급성뇌경사환자적병정급예후구유중요적림상의의.
Objective To investigate the clinical significance of plasma adrenocorticotropic hormone and cortisol changes at different time in acute cerebral infarction.Methods The clinical data of 62 patients with acute cerebral infarction (acute cerebral infarction group) were analyzed retrospectively,and 60 healthy cases in the same period were recruited as control group.The plasma adrenocorticotropic hormone and cortisol levels at 8:00,16:00 and 24:00 of two groups were detected by electrochemiluminescence immunoassay.Results Plasma adrenocorticotropic hormone and cortisol levels at 8:00,16:00 and 24:00 in acute cerebral infarction group were significantly higher than those in control group [(20.5 ± 4.2) pmol/L vs.(10.4 ±2.6) pmol/L,(18.9 ±4.9) pmol/L vs.(8.5 ± 2.1) pmol/L,(18.1 ±3.8) pmol/L vs.(7.1 ±2.4) pmol/L and (542 ± 76) nmol/L vs.(469 ± 65) nmol/L,(528 ±43) nmol/L vs.(341 ± 33) nmol/L,(499 ± 32) nmol/L vs.(196 ±27) nmol/L](P＜0.05); plasma adrenocorticotropic hormone and cortisol levels of severe degree acute cerebral infarction at different time were higher than those of light conditions (P＜0.05 ); plasma adrenocorticotropic hormone and cortisol levels at different time of acute cerebral infarction patients with good prognosis were significantly lower than those of the persons with poor prognosis(P＜0.05).Conclusion Plasma adrenocorticotropic hormone and cortisol testing at different time has clinical significance in determining the condition and prognosis of patients with acute cerebral infarction.
