CAJ | 학술논문

视神经脊髓炎(NMO)是一种自身免疫性炎性脱髓鞘性疾病,自身抗体攻击正常组织,其选择性的影响视神经和脊髓,造成视神经和脊髓的相继或同时受累.临床特点是急性或亚急性起病的单眼或双眼失明,在其前后数日或数周出现横惯性或上升性脊髓炎.近年来,对视神经脊髓炎的发病机制,病理学特点以及治疗方面的研究取得了巨大成就,其中水通道蛋白4(AQP4)的发现开辟了NMO研究的新领域,抗AQP4抗体参与致病过程并对疾病的诊断和判断预后具有重要作用因而深入研究视神经脊髓炎的发病机制和治疗方法对指导临床诊治、改善预后具有积极的意义.
시신경척수염(NMO)시일충자신면역성염성탈수초성질병,자신항체공격정상조직,기선택성적영향시신경화척수,조성시신경화척수적상계혹동시수루.림상특점시급성혹아급성기병적단안혹쌍안실명,재기전후수일혹수주출현횡관성혹상승성척수염.근년래,대시신경척수염적발병궤제,병이학특점이급치료방면적연구취득료거대성취,기중수통도단백4(AQP4)적발현개벽료NMO연구적신영역,항AQP4항체삼여치병과정병대질병적진단화판단예후구유중요작용인이심입연구시신경척수염적발병궤제화치료방법대지도림상진치、개선예후구유적겁적의의.
Neuromyelitis optica (NMO) is an autoimmune, inflammatory, demyelinating disease , autoantibodies target previously normal tissues and selectively affect the optic nerve and the spinal cord, resulting optic neuritis,transverse myelitis involved successively or simultaneously. Clinically characterized by acute or subacute onset of one or both eyes blind, in their few days or weeks before and after the emergence or increase myelitis tran sverse inertia. In recent years , many important achivements on the neuromyelitis optica have been obtained, among which the discovery of aquaporin 4 (AQP4) opened up new areas in the research on NMO,anti-AQP4 antibody participates pathogenesis and is important in diagnosis and prognosis of the disease. Research on the pathogenesis and treatment may provide positive strategy for the clinical diagnosis and improvement of prognosis.