中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
29期
17-19
,共3页
蔡凤林%何春兰%章佳新%周士福%时伟锋
蔡鳳林%何春蘭%章佳新%週士福%時偉鋒
채봉림%하춘란%장가신%주사복%시위봉
乳腺肿瘤%Twist蛋白%Ki-67抗原%微血管密度
乳腺腫瘤%Twist蛋白%Ki-67抗原%微血管密度
유선종류%Twist단백%Ki-67항원%미혈관밀도
Breast neoplasms%Twist protein%Ki-67 antigen%Microvascular density
目的 探讨Twist在乳腺浸润性导管癌中的表达及其与细胞增殖和血管生成的关系.方法 应用免疫组织化学法检测60例乳腺浸润性导管癌组织中Twist和Ki-67的表达情况,计算Ki-67指数和微血管密度(MVD).结果 乳腺浸润性导管癌组织中Twist阳性表达率为56.7％(34/60),Twist阳性患者Ki-67指数、MVD显著高于Twist阴性患者[(57.05±16.37)％比(25.32±16.16)％、(34.30±12.25)％比(23.04±10.45)％,P＜ 0.05].结论 乳腺浸润性导管癌组织中Twist高表达,Twist可促进肿瘤细胞增殖和肿瘤血管生成,从而成为其促进乳腺癌浸润、转移的途径之一.
目的 探討Twist在乳腺浸潤性導管癌中的錶達及其與細胞增殖和血管生成的關繫.方法 應用免疫組織化學法檢測60例乳腺浸潤性導管癌組織中Twist和Ki-67的錶達情況,計算Ki-67指數和微血管密度(MVD).結果 乳腺浸潤性導管癌組織中Twist暘性錶達率為56.7％(34/60),Twist暘性患者Ki-67指數、MVD顯著高于Twist陰性患者[(57.05±16.37)％比(25.32±16.16)％、(34.30±12.25)％比(23.04±10.45)％,P＜ 0.05].結論 乳腺浸潤性導管癌組織中Twist高錶達,Twist可促進腫瘤細胞增殖和腫瘤血管生成,從而成為其促進乳腺癌浸潤、轉移的途徑之一.
목적 탐토Twist재유선침윤성도관암중적표체급기여세포증식화혈관생성적관계.방법 응용면역조직화학법검측60례유선침윤성도관암조직중Twist화Ki-67적표체정황,계산Ki-67지수화미혈관밀도(MVD).결과 유선침윤성도관암조직중Twist양성표체솔위56.7％(34/60),Twist양성환자Ki-67지수、MVD현저고우Twist음성환자[(57.05±16.37)％비(25.32±16.16)％、(34.30±12.25)％비(23.04±10.45)％,P＜ 0.05].결론 유선침윤성도관암조직중Twist고표체,Twist가촉진종류세포증식화종류혈관생성,종이성위기촉진유선암침윤、전이적도경지일.
Objective To study the expression of Twist in invasive ductal carcinoma of breast and its relationship with cell proliferation and angiogenesis.Methods The expression of Twist and Ki-67 was detected in 60 cases with invasive ductal carcinoma of breast by immunohistochemistry.Ki-67 index and microvascular density (MVD) were calculated.Results The positive expression rate of Twist was 56.7％ (34/60) in invasive ductal carcinoma of breast.Ki-67 index and MVD in the patients with positive expression of Twist was higher than those in the patients with negative expression of Twist [(57.05 ± 16.37)％ vs.(25.32 ± 16.16)％,(34.30 ± 12.25)％ vs.(23.04 ± 10.45)％,P＜ 0.05 ].Conclusions The overexpression of Twist is found in invasive ductal carcinoma of breast.To stimulate cell proliferation and angiogenesis may be one of the pathways of Twist to contribute to the invasion and metastasis of breast cancer.
