中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
8期
33-34
,共2页
日间手术%术后认知功能障碍%S-100蛋白和神经特异性烯醇化酶
日間手術%術後認知功能障礙%S-100蛋白和神經特異性烯醇化酶
일간수술%술후인지공능장애%S-100단백화신경특이성희순화매
Day surgery%Postoperative cognitive dysfunction%S-10013 protein and Neuron-Specific Enolase
目的 本研究评估老年患者在日间手术后24 h内POCD发生,及血清神经损伤标志物-S-100蛋白和神经特异性烯醇化酶变化.方法 老年患者30例,随机分为异丙酚静脉麻醉组、七氟醚吸入麻醉组;观察在日间手术后24 h内POCD的发生,及血清神经损伤标志物S-100蛋白和神经特异性烯醇化酶变化.结果 POCD发生较对照组高,P=0.03.S-100蛋白和神经特异性烯醇化酶与对照组及术前没有显著变化.结论 老年患者在日间手术后24 h内POCD发生,较以往报道的大手术后7 d内发生高;S-100蛋白和神经特异性烯醇化酶水平无变化.
目的 本研究評估老年患者在日間手術後24 h內POCD髮生,及血清神經損傷標誌物-S-100蛋白和神經特異性烯醇化酶變化.方法 老年患者30例,隨機分為異丙酚靜脈痳醉組、七氟醚吸入痳醉組;觀察在日間手術後24 h內POCD的髮生,及血清神經損傷標誌物S-100蛋白和神經特異性烯醇化酶變化.結果 POCD髮生較對照組高,P=0.03.S-100蛋白和神經特異性烯醇化酶與對照組及術前沒有顯著變化.結論 老年患者在日間手術後24 h內POCD髮生,較以往報道的大手術後7 d內髮生高;S-100蛋白和神經特異性烯醇化酶水平無變化.
목적 본연구평고노년환자재일간수술후24 h내POCD발생,급혈청신경손상표지물-S-100단백화신경특이성희순화매변화.방법 노년환자30례,수궤분위이병분정맥마취조、칠불미흡입마취조;관찰재일간수술후24 h내POCD적발생,급혈청신경손상표지물S-100단백화신경특이성희순화매변화.결과 POCD발생교대조조고,P=0.03.S-100단백화신경특이성희순화매여대조조급술전몰유현저변화.결론 노년환자재일간수술후24 h내POCD발생,교이왕보도적대수술후7 d내발생고;S-100단백화신경특이성희순화매수평무변화.
Objective Postoperative cognitive dysfunction (POCD) is evident in 26% of elderly patients seven days after major non-cardiac surgery.Despite the growing popularity of day surgery,the influence of anesthetic techniques on next day POCD has not been investigated.Therefore,we evaluated the incidence of POCD and changes in serum markers of neuronal damage (S-100β protein and Neuron-Specific Enolase),24 hr after single-agent propofol or sevoflurane anesthesia in elderly patients undergoing minor surgery.Methods Patients (n=30,mean age 73,range 65-86 yr) coming for cystoscopy or hysteroscopy,were randomized,in an observer-blind design,to receive either single-agent propofol or sevoflurane anesthesia.Changes in S-10013 protein and Neuron-Specific Enolase levels were also documented.Results POCD Was present in 7/15 patients who received propofol and 7/15 patients who received sevoflurane,compared with 1/15 control patients,P=0.03.S100β protein and Neuron-Specific Enolase levels were not significantly different in anesthetized patients postoperatively compared with preoperative values.
