中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
15期
61-63
,共3页
宫颈癌%血管内皮生长因子%化疗
宮頸癌%血管內皮生長因子%化療
궁경암%혈관내피생장인자%화료
Cervical cancer%Vascular endothelial growth factor%Chemotherapy
目的 探讨血管内皮生长因子(VEGF)能否作为评判宫颈癌化疗近期疗效的预测指标,为制定合理的治疗方案提供参考.方法 采用酶联免疫吸附法(ELISA)监测60例宫颈鳞癌患者及20例正常健康妇女血清中的VEGF水平(P<0.01).结果 宫颈癌Ⅰ期血清VEGF值低于Ⅱ期者(P<0.05);宫颈癌患者术后血清VEGF表达较术前明显上升(P<0.01),术后化疗后血清VEGF水平较术后明显下降(P<0.01);宫颈癌Ⅰ期患者术后化疗后血清VEGF水平与术前比较差异无统计学意义(P>0.05),宫颈癌Ⅱa期、Ⅱb期患者术后化疗后血清VEGF水平均低于术前(P<0.05);宫颈癌Ⅱb期患者新辅助化疗(NACT)后血清VEGF浓度较NACT前降低(P<0.05).结论 VEGF可作为预测宫颈癌化疗近期疗效和判断术后是否需要辅助化疗及化疗疗程的参考指标.
目的 探討血管內皮生長因子(VEGF)能否作為評判宮頸癌化療近期療效的預測指標,為製定閤理的治療方案提供參攷.方法 採用酶聯免疫吸附法(ELISA)鑑測60例宮頸鱗癌患者及20例正常健康婦女血清中的VEGF水平(P<0.01).結果 宮頸癌Ⅰ期血清VEGF值低于Ⅱ期者(P<0.05);宮頸癌患者術後血清VEGF錶達較術前明顯上升(P<0.01),術後化療後血清VEGF水平較術後明顯下降(P<0.01);宮頸癌Ⅰ期患者術後化療後血清VEGF水平與術前比較差異無統計學意義(P>0.05),宮頸癌Ⅱa期、Ⅱb期患者術後化療後血清VEGF水平均低于術前(P<0.05);宮頸癌Ⅱb期患者新輔助化療(NACT)後血清VEGF濃度較NACT前降低(P<0.05).結論 VEGF可作為預測宮頸癌化療近期療效和判斷術後是否需要輔助化療及化療療程的參攷指標.
목적 탐토혈관내피생장인자(VEGF)능부작위평판궁경암화료근기료효적예측지표,위제정합리적치료방안제공삼고.방법 채용매련면역흡부법(ELISA)감측60례궁경린암환자급20례정상건강부녀혈청중적VEGF수평(P<0.01).결과 궁경암Ⅰ기혈청VEGF치저우Ⅱ기자(P<0.05);궁경암환자술후혈청VEGF표체교술전명현상승(P<0.01),술후화료후혈청VEGF수평교술후명현하강(P<0.01);궁경암Ⅰ기환자술후화료후혈청VEGF수평여술전비교차이무통계학의의(P>0.05),궁경암Ⅱa기、Ⅱb기환자술후화료후혈청VEGF수평균저우술전(P<0.05);궁경암Ⅱb기환자신보조화료(NACT)후혈청VEGF농도교NACT전강저(P<0.05).결론 VEGF가작위예측궁경암화료근기료효화판단술후시부수요보조화료급화료료정적삼고지표.
Objective To explore the feasibility of applying the vascular endothelial growth factor(VEGF) to predicting and evaluating cervical cancer chemotherapy by investigating the changes of VEGF before and after chemotherapy,so as to guide the rational treatment. Methods Using enzymelinked immunosorbent assay(ELISA) to detect and compare serum VEGF levels in 60 cases of cervical squamous cell carcinoma and 20 healthy women. Results Levels of serum VEGF in cervical carcinoma were significantly higher than those of normal healthy women (P<0.01),and the serum VEGF values of cervical cancer in stage Ⅰ were lower than those in stage Ⅱ(P<0.05).Expressions of serum VEGF in cervical cancer patients significantly increased after surgery compared with that before surgery(P< 0.01),and decreased significantly after postoperative chemotherapy compared with that after surgery (P<0.01),but the serum VEGF levels in stage Ⅰ cervical cancer patients after postoperative chemotherapy showed no significant difference compared with that before surgery (P<0.05),while those in stage Ⅱ a and Ⅱ b cervical cancer patients after postoperative chemotherapy were lower than those before surgery(P<0.05).The expressions of serum VEGF in stage Ⅱb cervical cancer patients after neoadjuvant chemotherapy(NACT) were lower than those before NACT (P<0.05).Conclusions VEGF can be used as an indicator for forecasting chemotherapy effects in cervical cancer and for determining whether to reinforce chemotherapy and postoperative chemotherapy regimen.
