中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
14期
41-42
,共2页
支气管肺炎%白细胞介素-12%肿瘤坏死因子-α%超敏C-反应蛋白%相关性
支氣管肺炎%白細胞介素-12%腫瘤壞死因子-α%超敏C-反應蛋白%相關性
지기관폐염%백세포개소-12%종류배사인자-α%초민C-반응단백%상관성
Bronchopneumonia%Interleukin-12%Tumor necrosis factor-α%High sensitivity C reactive protein%Relationship
目的 探讨白细胞介素-12(IL-12)、肿瘤坏死因子-α(TNF-α)和高敏C-反应蛋白(hs-CRP)在支气管肺炎发病过程中的作用以及三者间关系.方法 选择确诊为支气管肺炎的96例患者为研究组,另选50例健康体检者为对照组,检测两组血清中IL-12、TNF-α和hs-CRP的表达水平,采用病例对照研究对两组血清IL-12、TNF-α和hs-CRP进行分析.结果 ①研究组患者血清中IL-12、TNF-a和hs-CRP的水平明显高于对照组,差异有统计学意义(P＜0.01)；②不同病情患者血清中IL-12、TNF-α和hs-CRP的表达水平不同,病情重组三者的表达明显高于病情轻组,差异有统计学意义(P＜0.01)；③血清IL-12与TNF-α(r =0.41,P＜0.05)、IL-12和hs-CRP(r=0.42,P ＜0.05),TNF-α和hs-CRP(r =0.44,P＜0.05)均呈正相关.结论 IL-12、TNF-α和hs-CRP对支气管肺炎的发生、发展具有重要促进作用,病情越重,三者血清中的水平越高.早期联合检测血清IL-12、TNF-α和hs-CRP的水平可能对判断病情严重程度有一定价值.
目的 探討白細胞介素-12(IL-12)、腫瘤壞死因子-α(TNF-α)和高敏C-反應蛋白(hs-CRP)在支氣管肺炎髮病過程中的作用以及三者間關繫.方法 選擇確診為支氣管肺炎的96例患者為研究組,另選50例健康體檢者為對照組,檢測兩組血清中IL-12、TNF-α和hs-CRP的錶達水平,採用病例對照研究對兩組血清IL-12、TNF-α和hs-CRP進行分析.結果 ①研究組患者血清中IL-12、TNF-a和hs-CRP的水平明顯高于對照組,差異有統計學意義(P＜0.01)；②不同病情患者血清中IL-12、TNF-α和hs-CRP的錶達水平不同,病情重組三者的錶達明顯高于病情輕組,差異有統計學意義(P＜0.01)；③血清IL-12與TNF-α(r =0.41,P＜0.05)、IL-12和hs-CRP(r=0.42,P ＜0.05),TNF-α和hs-CRP(r =0.44,P＜0.05)均呈正相關.結論 IL-12、TNF-α和hs-CRP對支氣管肺炎的髮生、髮展具有重要促進作用,病情越重,三者血清中的水平越高.早期聯閤檢測血清IL-12、TNF-α和hs-CRP的水平可能對判斷病情嚴重程度有一定價值.
목적 탐토백세포개소-12(IL-12)、종류배사인자-α(TNF-α)화고민C-반응단백(hs-CRP)재지기관폐염발병과정중적작용이급삼자간관계.방법 선택학진위지기관폐염적96례환자위연구조,령선50례건강체검자위대조조,검측량조혈청중IL-12、TNF-α화hs-CRP적표체수평,채용병례대조연구대량조혈청IL-12、TNF-α화hs-CRP진행분석.결과 ①연구조환자혈청중IL-12、TNF-a화hs-CRP적수평명현고우대조조,차이유통계학의의(P＜0.01)；②불동병정환자혈청중IL-12、TNF-α화hs-CRP적표체수평불동,병정중조삼자적표체명현고우병정경조,차이유통계학의의(P＜0.01)；③혈청IL-12여TNF-α(r =0.41,P＜0.05)、IL-12화hs-CRP(r=0.42,P ＜0.05),TNF-α화hs-CRP(r =0.44,P＜0.05)균정정상관.결론 IL-12、TNF-α화hs-CRP대지기관폐염적발생、발전구유중요촉진작용,병정월중,삼자혈청중적수평월고.조기연합검측혈청IL-12、TNF-α화hs-CRP적수평가능대판단병정엄중정도유일정개치.
Objective To investigate the expresion of serum IL-12,TNF-α and hs-CRP in patients with bronchopneumonia and their relationship.Methods Ninety-six patients with bronchopneumonia were assigned to the study group,and other 50 health people were assigned to the control group.The serum levels of IL-12,TNF-α and hs-CRP were detected in the two groups,and the correlation among them was analyzed.Results ①The serum levels of IL-12,TNF-α and hs-CRP in the study group were obviously higher than those in the control group,there were significant differences( P ＜0.01 ).②The serum levels of IL-12,TNF-α and hs-CRP were obviously higher in the serious patients than those in the lighter patient,there were significant differences( P ＜0.01 ).③The plasma IL-12 was negative correlated with TNF-α (r =0.41,P ＜ 0.05),IL-12 was negative correlated with hs-CRP (r =0.42,P ＜ 0.05),and TNF-α also was negative correlated with hs-CRP in the observation group( r =0.44,P ＜0.05).Conclusions The higher level of IL-12,TNF-α and hs-CRP can induce the development of bronchopneumonia,the serious was bronchopneumonia,the serum level of IL-12,TNF-α and hs-CRP was higher.Early combined detection of these indicators can be used to judge the severity of bronchopneumonia.
