化学研究与应用
化學研究與應用
화학연구여응용
CHEMICAL RESEARCH AND APPLICATION
2009年
7期
1079-1082
,共4页
秦丙昌%陈静%朱文举%刘荣旺%许春霞
秦丙昌%陳靜%硃文舉%劉榮旺%許春霞
진병창%진정%주문거%류영왕%허춘하
2,6-二氯二苯胺%2,6-二氯苯氧乙酸甲酯%Smiles重排
2,6-二氯二苯胺%2,6-二氯苯氧乙痠甲酯%Smiles重排
2,6-이록이분알%2,6-이록분양을산갑지%Smiles중배
2,6-dichlorodiphenylamine%methyl 2,6-dichlorophenoxyacetate%Smiles rearrangement
A new method for synthesizing 2,6-dichlorodiphenylamine was presented in this article.2,6-dichlorodiphenylamine is the key intermediate for the preparing of diclofenac sodium.It was synthesized in a one-shot reaction with 2,6-dichlorophenol,a solution of sodium methoxide in methanol,methyl chloroacetate,aniline,and sodium hydroxide as raw materials by the acid-base neutralization,etherification,ammonolysis of ester,Smiles rearrangement of amide,and alcoholysis or hydrolysis of the rearrangement product.Based on many times of experiment,the best technological condition was found.The yield of target compound was about 91%.
