中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
6期
639-641
,共3页
赵志荣%潘立峰%武爱萍%郝世柱
趙誌榮%潘立峰%武愛萍%郝世柱
조지영%반립봉%무애평%학세주
高压氧%颅脑外伤%持续性植物状态
高壓氧%顱腦外傷%持續性植物狀態
고압양%로뇌외상%지속성식물상태
Hyperbaric oxygen%Traumatic brain injury%Persistent vegetative state
目的 探讨高压氧对持续性植物状态(PVS)患者康复治疗的效果和作用机制.方法 采用高压氧加常规治疗对62例PVS患者进行治疗.(1)高压氧治疗:采用高压氧气舱,空气加压0.18～0.20 MPa.用面罩接氧气呼吸器后吸氧30 min、共2次,中间休息10 min.每日1次,10次为1个疗程,平均4～6疗程.(2)常规治疗:所有患者在高压氧治疗的同时均给予药物治疗,包括止血、脱水、抗感染、神经细胞营养剂、促醒剂及对症支持疗法.按病程长短分为A组(26 ～59 d)26例、B组(60～119 d)24例和C组(120～268 d)12例共3组,观察分析不同病程与高压氧疗效的关系.结果 经高压氧加常规治疗后,PVS患者基本痊愈27例(43.5％),明显好转18例(29.0％),好转8例(12.9％),无效9例(14.5％),总有效率达85.5％(53/62).高压氧加常规治疗的疗效与患者的病程长短有关,3组不同病程患者疗效(A组96.2％,B组为62.5％,C组41.7％)之间差异有统计学意义(x2=24.83,P＜0.01),PVS患者病程越短疗效越好.结论 高压氧加常规治疗能促进持续性植物状态患者苏醒和生命功能的维持.
目的 探討高壓氧對持續性植物狀態(PVS)患者康複治療的效果和作用機製.方法 採用高壓氧加常規治療對62例PVS患者進行治療.(1)高壓氧治療:採用高壓氧氣艙,空氣加壓0.18～0.20 MPa.用麵罩接氧氣呼吸器後吸氧30 min、共2次,中間休息10 min.每日1次,10次為1箇療程,平均4～6療程.(2)常規治療:所有患者在高壓氧治療的同時均給予藥物治療,包括止血、脫水、抗感染、神經細胞營養劑、促醒劑及對癥支持療法.按病程長短分為A組(26 ～59 d)26例、B組(60～119 d)24例和C組(120～268 d)12例共3組,觀察分析不同病程與高壓氧療效的關繫.結果 經高壓氧加常規治療後,PVS患者基本痊愈27例(43.5％),明顯好轉18例(29.0％),好轉8例(12.9％),無效9例(14.5％),總有效率達85.5％(53/62).高壓氧加常規治療的療效與患者的病程長短有關,3組不同病程患者療效(A組96.2％,B組為62.5％,C組41.7％)之間差異有統計學意義(x2=24.83,P＜0.01),PVS患者病程越短療效越好.結論 高壓氧加常規治療能促進持續性植物狀態患者囌醒和生命功能的維持.
목적 탐토고압양대지속성식물상태(PVS)환자강복치료적효과화작용궤제.방법 채용고압양가상규치료대62례PVS환자진행치료.(1)고압양치료:채용고압양기창,공기가압0.18～0.20 MPa.용면조접양기호흡기후흡양30 min、공2차,중간휴식10 min.매일1차,10차위1개료정,평균4～6료정.(2)상규치료:소유환자재고압양치료적동시균급여약물치료,포괄지혈、탈수、항감염、신경세포영양제、촉성제급대증지지요법.안병정장단분위A조(26 ～59 d)26례、B조(60～119 d)24례화C조(120～268 d)12례공3조,관찰분석불동병정여고압양료효적관계.결과 경고압양가상규치료후,PVS환자기본전유27례(43.5％),명현호전18례(29.0％),호전8례(12.9％),무효9례(14.5％),총유효솔체85.5％(53/62).고압양가상규치료적료효여환자적병정장단유관,3조불동병정환자료효(A조96.2％,B조위62.5％,C조41.7％)지간차이유통계학의의(x2=24.83,P＜0.01),PVS환자병정월단료효월호.결론 고압양가상규치료능촉진지속성식물상태환자소성화생명공능적유지.
Objective To investigate the efficacy and mechanism of hyperbaric oxygen combining conventional therapy on persistent vegetative state ( PVS).Methods Sixty-two cases of PVS patients were treated with hyperbaric oxygen ( HBO ) combinting with conventional therapy.( 1 ) Hyperbaric oxygen therapy:hyperbaric oxygen chamber was adopted and the air pressure was 0,18 -0.20 MPa.The patients breathed pure oxygen for 30 min,2 times per day with a 10 min interval,and continued for 10 days as a course with an average of 4 to 6 courses.(2)Conventional therapy:All patients received drug treatment in hyperbaric oxygen therapy at the same time,including hemostasis,dehydration,anti-infection,nerve cell nutrition agents,wake promoting agents and supportive therapy.All patients were divided to three groups according to the course of disease:26 - 59 days in A group,60-119 days in B group,120 -268 days in C group,and the relationship between disease course and HBO treatment efficacy was analyzed.Results Afer HBO combining conventional therapy,27 cases (43.5％) were recovered,18 cases(29.0％ ) had obvious effect,8 cases( 12.9％ ) had effect,9 cases( 14.5％ )were inefficacy.The efficiency related to the course of disease.The total efficiency rate was 85.5％.The efficacy of HBO treatment had significant difference in A,B and C group ( 96.2％,62.5％ and 41.7％ in A,B and C group respectively,x2 =24.83,P ＜ 0.01 ).The shorter course indicated the better efficacy.Conclusion Hyperbaric oxygen combining conven.
