CAJ | 학술논문

目的探讨肾素-血管紧张素-醛固酮系统、内皮素、一氧化氮在肾血管性高血压患者、肾上腺腺瘤患者中的作用和意义.方法采用放射免疫分析的方法测量肾血管性高血压组(40例)、肾上腺腺瘤组(35例)和健康对照组(35例)血清肾素、血管紧张素Ⅱ、醛固酮、内皮素含量,用酶免疫法测定上述人群一氧化氮合酶(NOS)的含量来表示NO的量.结果肾血管性高血压患者肾素、血管紧张素、醛固酮、内皮素含量高于健康对照组(P＜0.01),NOS含量低于健康对照组(P＜0.05);肾上腺腺瘤组醛固酮和内皮素含量高于健康对照组(P＜0.01),肾素、血管紧张素低于健康对照组(P＜0.05).结论肾索、血管紧张素、醛固酮、内皮素和NO的检测可为临床早期诊断肾上腺腺瘤、肾血管性高血压提供依据.
목적 탐토신소-혈관긴장소-철고동계통、내피소、일양화담재신혈관성고혈압환자、신상선선류환자중적작용화의의.방법 채용방사면역분석적방법측량신혈관성고혈압조(40례)、신상선선류조(35례)화건강대조조(35례)혈청신소、혈관긴장소Ⅱ、철고동、내피소함량,용매면역법측정상술인군일양화담합매(NOS)적함량래표시NO적량.결과 신혈관성고혈압환자신소、혈관긴장소、철고동、내피소함량고우건강대조조(P＜0.01),NOS함량저우건강대조조(P＜0.05);신상선선류조철고동화내피소함량고우건강대조조(P＜0.01),신소、혈관긴장소저우건강대조조(P＜0.05).결론 신색、혈관긴장소、철고동、내피소화NO적검측가위림상조기진단신상선선류、신혈관성고혈압제공의거.
Objective To investigate the roles of renin-angiotens in system(RAS)and aldosterone(ALD),endothelin(ET),nitricoxide(NO)in patients with renal hypertension(40 cases)and adrenocorticoadenomas(35 cases),35 normal subjects were included in the study as controls.Methods Radioimmunoassay(RIA)was used to de termine the plasma concentrations of the renin,angiorensin Ⅱ(AⅡ),aldosterone,ET in the abovecases.Enzymicas say was adopted to examine the plasma concentration of the nitricoxidesynthase(NOS).Results TIhe plasma concentrations of renin,angiotennsin Ⅱ,aldosterone,endothefin in the patients with renal hypertension were significantly higher than those in the control group(P＜0.01)except with the concentration of NOS,which were lower than that in controls(P＜0.05);the plasma concentrations of the ALD,ET,in the patients with adrenocorti-caladenoma were higher that those in controls(P＜0.01)but renin and A Ⅱ were lower(P＜0.05).Conclusion Determination of the plasma renin,angiotensionⅡ,aldosterone and NO might be able diagnose renal hypertension and adrenocorti coadenoma earlier.