中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2012年
4期
310-313
,共4页
阴晓娟%邓振生%张秀春%吴君心%潘建基
陰曉娟%鄧振生%張秀春%吳君心%潘建基
음효연%산진생%장수춘%오군심%반건기
动态对比度增强灌注磁共振成像,T1加权%微血管通透性%脑肿瘤/放射疗法%靶体积勾画
動態對比度增彊灌註磁共振成像,T1加權%微血管通透性%腦腫瘤/放射療法%靶體積勾畫
동태대비도증강관주자공진성상,T1가권%미혈관통투성%뇌종류/방사요법%파체적구화
Dynamic contrast-enhanced perfusion magnetic resonance imaging,T1-weighted%Microvascular permeability%Brain neoplasms/radiotherapy%Delineation of target volume
目的 探讨利用T1加权动态对比度增强灌注MRI( DCEPMRI)技术在放疗中确定脑胶质瘤临床靶区的研究.方法 对28例脑胶质瘤患者团注顺磁性造影剂Gd-DTPA后,采集其T1加权DCEPMRI,对获得图像用改进的Tofts-Kermode两室分析模型和反卷积法进行处理分析得到微血管通透性相关定量参数Ktrans值及图,并比较最大病灶区所在层面常规增强MRI与T1加权DCEPMRI的Ktrans值及图,测量各个临床级别脑胶质瘤病灶面积差异.结果 低级别胶质瘤微血管通透性较低、肿瘤浸润范围小,T1加权DCEPMRI与常规增强MRI所测病灶面积误差达0 2％～0 3％[Ⅰ、Ⅱ级分别为2.93 cm2∶2.46 cm2(t =6.90,P=0.000)、4.18 cm2∶3.21 cm2(t =10.22,P=0.000)];高级别胶质瘤微血管通透性较高、肿瘤浸润范围大,T1加权DCEPMRI与常规增强MRI所测量病灶面积误差达25.1％ ～26.3％[Ⅲ、Ⅳ级分别为6.46 cm2∶5.48 cm2(t=10.83,P =0.000)、8.26 cm2∶6.52 cm2(t=18.53,P=0.000)].结论 以T1加权DCEPMRI技术得到的微血管通透性相关定量参数Ktrans值及彩图为胶质瘤放疗靶区确定提供了更为准确信息,可作为评价肿瘤体积新方法.
目的 探討利用T1加權動態對比度增彊灌註MRI( DCEPMRI)技術在放療中確定腦膠質瘤臨床靶區的研究.方法 對28例腦膠質瘤患者糰註順磁性造影劑Gd-DTPA後,採集其T1加權DCEPMRI,對穫得圖像用改進的Tofts-Kermode兩室分析模型和反捲積法進行處理分析得到微血管通透性相關定量參數Ktrans值及圖,併比較最大病竈區所在層麵常規增彊MRI與T1加權DCEPMRI的Ktrans值及圖,測量各箇臨床級彆腦膠質瘤病竈麵積差異.結果 低級彆膠質瘤微血管通透性較低、腫瘤浸潤範圍小,T1加權DCEPMRI與常規增彊MRI所測病竈麵積誤差達0 2％～0 3％[Ⅰ、Ⅱ級分彆為2.93 cm2∶2.46 cm2(t =6.90,P=0.000)、4.18 cm2∶3.21 cm2(t =10.22,P=0.000)];高級彆膠質瘤微血管通透性較高、腫瘤浸潤範圍大,T1加權DCEPMRI與常規增彊MRI所測量病竈麵積誤差達25.1％ ～26.3％[Ⅲ、Ⅳ級分彆為6.46 cm2∶5.48 cm2(t=10.83,P =0.000)、8.26 cm2∶6.52 cm2(t=18.53,P=0.000)].結論 以T1加權DCEPMRI技術得到的微血管通透性相關定量參數Ktrans值及綵圖為膠質瘤放療靶區確定提供瞭更為準確信息,可作為評價腫瘤體積新方法.
목적 탐토이용T1가권동태대비도증강관주MRI( DCEPMRI)기술재방료중학정뇌효질류림상파구적연구.방법 대28례뇌효질류환자단주순자성조영제Gd-DTPA후,채집기T1가권DCEPMRI,대획득도상용개진적Tofts-Kermode량실분석모형화반권적법진행처리분석득도미혈관통투성상관정량삼수Ktrans치급도,병비교최대병조구소재층면상규증강MRI여T1가권DCEPMRI적Ktrans치급도,측량각개림상급별뇌효질류병조면적차이.결과 저급별효질류미혈관통투성교저、종류침윤범위소,T1가권DCEPMRI여상규증강MRI소측병조면적오차체0 2％～0 3％[Ⅰ、Ⅱ급분별위2.93 cm2∶2.46 cm2(t =6.90,P=0.000)、4.18 cm2∶3.21 cm2(t =10.22,P=0.000)];고급별효질류미혈관통투성교고、종류침윤범위대,T1가권DCEPMRI여상규증강MRI소측량병조면적오차체25.1％ ～26.3％[Ⅲ、Ⅳ급분별위6.46 cm2∶5.48 cm2(t=10.83,P =0.000)、8.26 cm2∶6.52 cm2(t=18.53,P=0.000)].결론 이T1가권DCEPMRI기술득도적미혈관통투성상관정량삼수Ktrans치급채도위효질류방료파구학정제공료경위준학신식,가작위평개종류체적신방법.
Objective To investigate whether the T1-weighted dynamic contrast-enhanced perfusion magnetic resonance imaging (DCEPMRI) technique can help to delineate the clinical target volume of brain glioma patients.Methods The DCE T1-weighted images from 28 glioma patients were collected after GdDTPA was injected.After the acquired images were processed and analyzed using modified Tofts-Kermode'two compartment analysis model and de-convolution method,the value and its pseudo mapping of quantitative parameter Ktrans related to microvascular permeability were obtained.The tumor size in the largest diameter slice measured both in routine enhanced MRI and Ktrans mapping of T1-weighted DCEPMRI were compared.Results The vascular permeability and tumor infiltration was lower in low grade glioma,the difference of the tumor size between T1-weighted DCEPMRI and routine enhanced MRI reached 0.2％ -0.3％ there was significant difference of tumor size between T1 -weighted DCEPMRI and routine enhanced MRI ( grade Ⅰ and Ⅱ grade with 2.93 cm2∶2.46 cm2(t=6.90,P=0.000) and 4.18 cm2∶3.21 cm2(t=10.22,P=0.000) ).While in high grade glioma,the vascular permeability and the tumor infiltration were higher,the difference of the tumor size between T1-weighted DCEPMRI and routine enhanced MRI reached 25％ - 26％( the size of grade Ⅲ and Ⅳ were 6.46 cm2 vs 5.48 cm2 ( t =10.83,P =0.000) and 8.26 cm2 vs 6.52 cm2(t =18.53,P =0.000) ).Conclusions The pseudo mapping of quantitative parameter Ktrans related to microvascular permeability acquired by T1-weighted DCEPMRI reflect the infiltrating circumscription in glioma,T1-weighted DCEPMRI can provide more information in delineation the clinical target volume,and it can be used as a new method for tumor volume evaluation.
