中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2009年
6期
405-406
,共2页
红斑狼疮,系统性%中枢神经系统感染%危险因素
紅斑狼瘡,繫統性%中樞神經繫統感染%危險因素
홍반랑창,계통성%중추신경계통감염%위험인소
Lupus erythematosus,systemic%Central nervous system infection%Risk factors
目的 分析系统性红斑狼疮(SLE)合并中枢神经系统(CNS)感染的临床特点及相关危险因素.方法 对18例诊断为SLE合并CNS感染的患者和随机抽取的36例SLE患者的临床资料进行回顾性分析.结果 CNS感染组与对照组在大剂量激素冲击(22%与3%,P<0.05),1年内日平均激素用量[(35±18)mg/d与(24±17)mg/d,P<0.05],外周血白细胞[(4.4±3.4)×109/L与(6.7±2.9)×109/L,P<0.05]、淋巴细胞计数[(0.7±0.6)×109/L与(1.5±0.7)×109/L,P<0.01]和临床转归(病死率22%与0,P<0.05)方面的差异有统计学意义.结论 SLE患者合并CNS感染的临床表现不典型.大剂量激素冲击治疗,日平均激素剂量大以及外周血白细胞、淋巴细胞减少是SLE患者发生CNS感染的危险因素.
目的 分析繫統性紅斑狼瘡(SLE)閤併中樞神經繫統(CNS)感染的臨床特點及相關危險因素.方法 對18例診斷為SLE閤併CNS感染的患者和隨機抽取的36例SLE患者的臨床資料進行迴顧性分析.結果 CNS感染組與對照組在大劑量激素遲擊(22%與3%,P<0.05),1年內日平均激素用量[(35±18)mg/d與(24±17)mg/d,P<0.05],外週血白細胞[(4.4±3.4)×109/L與(6.7±2.9)×109/L,P<0.05]、淋巴細胞計數[(0.7±0.6)×109/L與(1.5±0.7)×109/L,P<0.01]和臨床轉歸(病死率22%與0,P<0.05)方麵的差異有統計學意義.結論 SLE患者閤併CNS感染的臨床錶現不典型.大劑量激素遲擊治療,日平均激素劑量大以及外週血白細胞、淋巴細胞減少是SLE患者髮生CNS感染的危險因素.
목적 분석계통성홍반랑창(SLE)합병중추신경계통(CNS)감염적림상특점급상관위험인소.방법 대18례진단위SLE합병CNS감염적환자화수궤추취적36례SLE환자적림상자료진행회고성분석.결과 CNS감염조여대조조재대제량격소충격(22%여3%,P<0.05),1년내일평균격소용량[(35±18)mg/d여(24±17)mg/d,P<0.05],외주혈백세포[(4.4±3.4)×109/L여(6.7±2.9)×109/L,P<0.05]、림파세포계수[(0.7±0.6)×109/L여(1.5±0.7)×109/L,P<0.01]화림상전귀(병사솔22%여0,P<0.05)방면적차이유통계학의의.결론 SLE환자합병CNS감염적림상표현불전형.대제량격소충격치료,일평균격소제량대이급외주혈백세포、림파세포감소시SLE환자발생CNS감염적위험인소.
Objective To investigate the clinic features and risk factors for central nervous system (CNS) infection in patients with systemic lupus erythematosus. Methods Clinical data of 18 cases of hospitalized lupus patients with CNS infection were analyzed retrospectively.Thirty-three lupus patients without CNS infection were selected as control. Results There were significant differences between the CNS infection group and control group in the dosage of corticosteroid used for pulse therapy (22% vs 3%, P<0.05), the aver-age dosage of corticosteroid used within one year (35±18 vs 24±17, P<0.05), peripheral blood leukocyte count (4.4±3.4 vs 6.7±2.9, P<0.05) and lymphocyte count (0.7±0.6 vs 1.5±0.7, P<0.01), and clinical outcome (mortality rate was 22% vs 0, P<0.05). Conclusion The clinical manifestations of CNS infection may be atypical. Large-dosage corticosteroid therapy, higher daily dosage of corticosteroid used, decreased peripheral lymphocytes and leucocytes counts are risk factors of central nervous system infection in lupus patients.
