CAJ | 학술논문

A型激酶锚定蛋白12(AKAP12)是一种细胞支架蛋白,能够锚定一些关键信号分子,如蛋白激酶A(PKA)、蛋白激酶C(PKC)和细胞周期素D1(cyclin D1),以及动态调节β2-肾上腺素受体复合物.AKAP12在多条信号转导通路中发挥重要作用.研究发现,AKAP12在前列腺癌、食管癌、胃癌等多种肿瘤中表达下调或缺失,是一个肿瘤抑制基因,同时也是潜在的肿瘤转移抑制基因.
A형격매묘정단백12(AKAP12)시일충세포지가단백,능구묘정일사관건신호분자,여단백격매A(PKA)、단백격매C(PKC)화세포주기소D1(cyclin D1),이급동태조절β2-신상선소수체복합물.AKAP12재다조신호전도통로중발휘중요작용.연구발현,AKAP12재전렬선암、식관암、위암등다충종류중표체하조혹결실,시일개종류억제기인,동시야시잠재적종류전이억제기인.
A-kinase anchoring protein 12 (AKAP12) ,is a kind of cell scaffold proteins,and can organize the complex of protein kinase A(PKA) and PKC as well as other signal molecules such as cyclin D1,and it is an important regulator of the β2-adrenergic receptor complex,which demonstrates the participation of AKAP12 in diverse signal transduction pathways.AKAP12 contains deletions or downregulation in variours tumors,including prostate cancers,gastric carcinomas and esophagus cancer,suggesting that the inactivation of AKAP12 expression may be linked to oncogenesis.AKAP12 is also a potential suppressor gene in metastasis of cancers.