CAJ | 학술논문

热休克蛋白是从细菌到人类均广泛存在的一类热应急蛋白质,并且广泛参与了机体的免疫调节过程.支气管哮喘(简称哮喘)是一种气道慢性炎症性疾病,亦被认为是一种自身免疫性疾病,其发病率逐年上升,已成为全球普遍关注、严重危害公众健康的常见病.目前,细胞免疫功能紊乱被视为哮喘的重要发病机制.越来越多的证据表明,热休克蛋白极可能参与哮喘的发病过程.
열휴극단백시종세균도인류균엄범존재적일류열응급단백질,병차엄범삼여료궤체적면역조절과정.지기관효천(간칭효천)시일충기도만성염증성질병,역피인위시일충자신면역성질병,기발병솔축년상승,이성위전구보편관주、엄중위해공음건강적상견병.목전,세포면역공능문란피시위효천적중요발병궤제.월래월다적증거표명,열휴극단백겁가능삼여효천적발병과정.
Heat shock proteins are a series of widespread proteins due to heat stress from bacteria to human, which are broadly participate in the process of immune regulation. Bronchial asthma (asthma)is a chronic airway inflammatory disease, which is also considered an autoimmune disease. With asthmatic incidence increased year by year, it causes a global common concern and become a common disease that is seriously danger to public health. Nowadays, the cellular immune dysfunction is considered important to the pathogenesis of asthma. There is growing evidence that heat shock proteins are likely involved in the pathogenesis of asthma.