国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2010年
1期
19-22
,共4页
血管内皮生长因子%受体,血管内皮生长因子%肿瘤%放射性核素显像
血管內皮生長因子%受體,血管內皮生長因子%腫瘤%放射性覈素顯像
혈관내피생장인자%수체,혈관내피생장인자%종류%방사성핵소현상
Vascular endothelial growth factors%Receptors,vascular endothelial growth factor%Neoplasms%Radionuclide imaging
肿瘤血管生成是肿瘤生长与转移生物学行为的重要基础.血管内皮生长因子(VEGF)及共受体(VEGFR)在肿瘤血管生成过程中起到了关键性的作用.VEGFR已成为目前肿瘤血管生成的诊断和治疗研究领域具有潜在应用价值的分子靶点.放射性核素受体显像具有灵敏度高、特异性强的优点,能够客观、准确显示体内肿瘤组织VEGFR的分布、密度及与其配体的结合亲和力,有助于肿瘤的诊断与鉴别诊断、临床分期、复发与转移的探测,并对临床实施针对VEGFR的肿瘤生物治疗具有积极的指导作用.
腫瘤血管生成是腫瘤生長與轉移生物學行為的重要基礎.血管內皮生長因子(VEGF)及共受體(VEGFR)在腫瘤血管生成過程中起到瞭關鍵性的作用.VEGFR已成為目前腫瘤血管生成的診斷和治療研究領域具有潛在應用價值的分子靶點.放射性覈素受體顯像具有靈敏度高、特異性彊的優點,能夠客觀、準確顯示體內腫瘤組織VEGFR的分佈、密度及與其配體的結閤親和力,有助于腫瘤的診斷與鑒彆診斷、臨床分期、複髮與轉移的探測,併對臨床實施針對VEGFR的腫瘤生物治療具有積極的指導作用.
종류혈관생성시종류생장여전이생물학행위적중요기출.혈관내피생장인자(VEGF)급공수체(VEGFR)재종류혈관생성과정중기도료관건성적작용.VEGFR이성위목전종류혈관생성적진단화치료연구영역구유잠재응용개치적분자파점.방사성핵소수체현상구유령민도고、특이성강적우점,능구객관、준학현시체내종류조직VEGFR적분포、밀도급여기배체적결합친화력,유조우종류적진단여감별진단、림상분기、복발여전이적탐측,병대림상실시침대VEGFR적종류생물치료구유적겁적지도작용.
Tumor angiogenesis is the foundation of tumor growth and metastasis. The vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) plays a pivotal role in regulating tumor angiogenesis. VEGFR has become a common molecular target which has a potential value in angiogenesis diagnosis and therapy at present. Radionuclide receptor imaging has the advantage of high sensitivity and specificity, by which distribution density of VEGFR and its affinity with its ligand in tumor tissue can be revealed. VEGFR imaging is helpful in diagnosis, staging and detection of recurrence and metastasis of tumor and plays an instructive role in biological therapy of tumor mediated by VEGFR.
