CAJ | 학술논문

目的评估标准化屋尘螨变应原特异性免疫治疗(specific immunotherapy,SIT)对儿童变应性鼻炎合并哮喘的临床疗效.方法选择我院42例接受标准化屋尘螨SIT的变应性鼻炎合并哮喘儿童为研究对象.所有患儿治疗前、治疗1年后均进行变应原皮肤点刺试验、测定血清屋尘螨和粉尘螨特异性IgE水平、进行肺功能测定和自觉症状评分.结果治疗1年后屋尘螨和粉尘螨的皮肤指数和自觉症状评分均较治疗前显著降低(P＜0.01,P＜0.05),而治疗前后屋尘螨和粉尘螨特异性IgE水平、肺功能(肺活量、第1秒用力呼气量、最大呼气中段流量)均无明显变化(P＞0.05).结论变应性鼻炎合并哮喘儿童给予SIT1年后其皮肤敏感性显著改善,临床症状明显好转,但对气道炎症的影响有待于进一步的观察.
목적 평고표준화옥진만변응원특이성면역치료(specific immunotherapy,SIT)대인동변응성비염합병효천적림상료효.방법 선택아원42례접수표준화옥진만SIT적변응성비염합병효천인동위연구대상.소유환인치료전、치료1년후균진행변응원피부점자시험、측정혈청옥진만화분진만특이성IgE수평、진행폐공능측정화자각증상평분.결과 치료1년후옥진만화분진만적피부지수화자각증상평분균교치료전현저강저(P＜0.01,P＜0.05),이치료전후옥진만화분진만특이성IgE수평、폐공능(폐활량、제1초용력호기량、최대호기중단류량)균무명현변화(P＞0.05).결론 변응성비염합병효천인동급여SIT1년후기피부민감성현저개선,림상증상명현호전,단대기도염증적영향유대우진일보적관찰.
Objective To evaluate the clinical efficacy of standardized house dust mite allergen specific immunotherapy (SIT) for rhinitis and asthma in children. Methods Forty-two children with allergic rhinitis and asthma who received a standardized house dust mite allergen SIT in our hospital were enrolled in our study. The result of allergen skin prick test, serum specific IgE levels (sIgE) of house dust mite and dust mite,pulmonary function and symptom scores were analysed before and at one year after treatment in all children. Results Skin indexes of house dust mite and dust mite, symptom score were significantly decreased at one year after treatment,but the levels of house dust mite and dust mite sIgE,lung function test (FVC,FEVt,MEF25-75) showed no significant differences. Conclusion Children with allergic rhinitis and asthma have significant improvements in their skin sensitivity and clinical symptoms by given SIT for one year,but the impact of SIT on airway inflammation needs further observation.