CAJ | 학술논문

目的探讨彩色多普勒超声检查肾血流与骨形态发生蛋白-7(BMP-7)水平检测在2型糖尿病肾病中的诊断价值.方法检测90例糖尿病肾病患者与30例健康志愿者血BMP-7水平,并经彩色多普勒超声测量肾血流动力学参数,比较各组血BMP-7水平、肾段动脉及肾叶间动脉阻力指数(RI).结果与对照组比较,随着糖尿病肾损害程度加重,BMP-7水平逐渐降低(P＜0.01),肾段动脉、肾叶间动脉收缩期最大血流速度及舒张末期最低血流速度逐渐减慢,RI增高(P＜0.01).BMP-7水平与肾段动脉、叶间动脉RI间存在显著负相关(r=-0.603,P＜0.01;r=-0.652,P＜0.01).结论彩色多普勒超声测量肾血流动力学参数联合检测血BMP-7水平对早期预测糖尿病肾病的肾损害程度有重要价值.
목적 탐토채색다보륵초성검사신혈류여골형태발생단백-7(BMP-7)수평검측재2형당뇨병신병중적진단개치.방법 검측90례당뇨병신병환자여30례건강지원자혈BMP-7수평,병경채색다보륵초성측량신혈류동역학삼수,비교각조혈BMP-7수평、신단동맥급신협간동맥조력지수(RI).결과 여대조조비교,수착당뇨병신손해정도가중,BMP-7수평축점강저(P＜0.01),신단동맥、신협간동맥수축기최대혈류속도급서장말기최저혈류속도축점감만,RI증고(P＜0.01).BMP-7수평여신단동맥、협간동맥RI간존재현저부상관(r=-0.603,P＜0.01;r=-0.652,P＜0.01).결론 채색다보륵초성측량신혈류동역학삼수연합검측혈BMP-7수평대조기예측당뇨병신병적신손해정도유중요개치.
Objective To evaluate the significance of color Doppler ultrasound examination of renal blood flow combined with the detection of bone morphogenetic protein-7(BMP-7)in early diagnosis of type 2 diabetic nephropathy.Methods Blood BMP-7 level was tested in 90 patients with type 2 diabetic nephropathy and 30 controls,and parameters of renal blood flow were measured by color Doppler ultrasound examination.Blood BMP-7 level as well as resistant index(RI)of segmental renal artery(SRA)and interlobar renal artery(IRA),were compared between these two groups.Results Compared with controls,blood BMP-7 level gradually decreased with the aggravation of diabetic kidney damage(P＜0.01).The peak systolic velocity(Vmax)and the end diastolic velocity(Vmin)of SRA and TRA were slowed gradually,while RI increased(P＜0.01).Blood BMP-7 level was negatively correlated with IRA's and SRA's RI of IRA and SRA(r =-0.603,P＜0.01;r =-0.652,P＜0.01).Conclusions Color Doppler ultrasound examination of renal blood flow combined with detection of BMP-7 might play an important role in early diagnosis of type 2 diabetic nephropathy.