CAJ | 학술논문

目的:观察无创伤经颅脉冲磁刺激(PTMS)对青霉素所致大脑皮质痫样放电(CCED)的作用,进一步探讨 PTMS作用于大脑皮质及小脑蚓部后,对 CCED作用的可能机制. 方法:选用 Wistar 大鼠48只,以CCED频率和幅度为指标,观察 PTMS一侧大鼠大脑皮质、小脑蚓部对青霉素所致 CCED的影响. 结果: PTMS一侧大脑, CCED频率明显降低了(36±10)% (t=3.873, P<0.01),其幅度也平均降低了(21±8)% (t=2.984,P<0.05); PTMS小脑蚓部的抑制效应持续的时间较 PTMS大脑皮质的作用时间长,停止 PTMS小脑蚓部 30 min后, CCED频率仍降低了(63±7)% (t=-3.497, P<0.001);侧脑室注射纳洛酮可部分翻转 PTMS的抑制作用. 结论: PTMS大脑皮质和小脑蚓部可明显抑制 CCED频率和幅度.
목적:관찰무창상경로맥충자자격(PTMS)대청매소소치대뇌피질간양방전(CCED)적작용,진일보탐토 PTMS작용우대뇌피질급소뇌인부후,대 CCED작용적가능궤제. 방법:선용 Wistar 대서48지,이CCED빈솔화폭도위지표,관찰 PTMS일측대서대뇌피질、소뇌인부대청매소소치 CCED적영향. 결과: PTMS일측대뇌, CCED빈솔명현강저료(36±10)% (t=3.873, P<0.01),기폭도야평균강저료(21±8)% (t=2.984,P<0.05); PTMS소뇌인부적억제효응지속적시간교 PTMS대뇌피질적작용시간장,정지 PTMS소뇌인부 30 min후, CCED빈솔잉강저료(63±7)% (t=-3.497, P<0.001);측뇌실주사납락동가부분번전 PTMS적억제작용. 결론: PTMS대뇌피질화소뇌인부가명현억제 CCED빈솔화폭도.
AIM:To observe the effect of pulse transcranial magnetic stimulation (PTMS) on the cerebral cortex epileptiform discharges (CCED) induced by penicillin sodium in rats and to investigate its possible mechanisms. METHODS:Epileptic rat models were established in 48 Wistar rats by penicillin, in which the frequency and amplitude of the epileptiform discharges were used as indexes to assess the effects of PTMS of the unilateral cerebral cortex and cerebellar vermis on CCED. RESULTS:After PTMS of the unilateral cerebral cortex,CCED frequency was significantly decreased by (36±10)% (t=3.873,P<0.01), with the amplitude decreased by (21±8)% (t=2.984,P<0.05).The lasting time of inhibitory effect produced by TIMS of the cerebellar vermis was longer than that generated by stimulation of the unilateral cerebral cortex. Thirty minutes after the termination of PTMS, the CCED frequency decreased by (63±7)% (t=-3.497,P<0.001).The inhibitory effect produced by PTMS were partially reversed by naloxone injected into the lateral ventricles. CONCLUSION:PTMS of the cerebral cortex and cerebellar vermis may have significant inhibitory effects on CCED.