CAJ | 학술논문

目的探讨洋参二醇皂苷注射液(IPQDS)对急性心肌梗死犬心肌氧代谢及冠脉循环的影响.方法麻醉开胸结扎犬左冠状动脉前降支6 h建立急性心肌梗死模型,同时静脉滴注 IPQDS 5、10、20 mg/kg 进行治疗,以CORNIHG 178型血气分析仪测定动、静脉血氧含量,观察心肌氧代谢变化,通过MP-27型电磁流量计记录冠状动脉血流量及冠脉阻力,观察冠脉循环情况.结果与梗死模型组比较,静脉滴注 IPQDS 10、20 mg/kg,可使急性心肌梗死 6 h犬心肌氧利用率、心肌耗氧指数及心肌耗氧量均明显降低(P<0.05或P<0.01),心肌血流量明显增加,冠脉血管阻力明显降低(P<0.05或P<0.01),IPQDS 5 mg/kg对上述各参数均无明显影响(P>0.05).结论 IPQDS可通过改善冠脉循环增加心肌血液供给,同时降低心肌耗氧及降低心肌氧利用率发挥抗急性心肌缺血作用.
목적 탐토양삼이순조감주사액(IPQDS)대급성심기경사견심기양대사급관맥순배적영향.방법 마취개흉결찰견좌관상동맥전강지6 h건립급성심기경사모형,동시정맥적주 IPQDS 5、10、20 mg/kg 진행치료,이CORNIHG 178형혈기분석의측정동、정맥혈양함량,관찰심기양대사변화,통과MP-27형전자류량계기록관상동맥혈류량급관맥조력,관찰관맥순배정황.결과 여경사모형조비교,정맥적주 IPQDS 10、20 mg/kg,가사급성심기경사 6 h견심기양이용솔、심기모양지수급심기모양량균명현강저(P<0.05혹P<0.01),심기혈류량명현증가,관맥혈관조력명현강저(P<0.05혹P<0.01),IPQDS 5 mg/kg대상술각삼수균무명현영향(P>0.05).결론 IPQDS가통과개선관맥순배증가심기혈액공급,동시강저심기모양급강저심기양이용솔발휘항급성심기결혈작용.
Objective To approach the effects of injection of Panax quinquefolium diolsaponins(IPQDS) on the myocardial oxygen metabolism and the coronary circulation in dogs with acute myocardial infarction(AMI). Methods The AMI model was induced by myocardial infarction for 6 h in dogs of left anterior descending coronary occulusion. After 90 min of treatment by IPQDS, the blood oxygen of artery and vein were determined by analysis instrument of blood gas with CORNIHG 178 type. At the same time, the blood flow of coronary artery was determined by electromagnetism flowmeter with MP-27 type. Results After treated by IPQDS (in a dosage of 10 and 20 mg/kg iv drip for 90 min), the cardiac oxygen consumption, cardiac oxygen consumption index and myocardial oxygen utilization rate were decreased. Meanwhile the myocardial blood flow (MBF) was increased and coronary vascular resistance (CVR) was decreased significantly but IPQDS (in a dosage of 5 mg/kg iv drip for 90 min) had no significant effect on above-mentioned all parameters. Conclusions IPQDS has protective effects on AMI including improving the coronary circulation, increasing myocardial blood supply and decreasing cardiac oxygen consumption and myocardial oxygen utilization rate.