CAJ | 학술논문

雄激素具有广泛的生物学效应.雄激素及其受体广泛存在于心脑血管系统,并在缺血性脑血管病(ischemic cerebrovascular disease,ICVD)发生和发展的多个环节发挥着重要的保护作用.除参与调节ICVD发病的危险因素,如动脉粥样硬化、血脂异常、高血压、凝血-纤溶异常、肥胖、糖尿病等外,雄激素还具有神经保护作用.文章对雄激素在ICVD中的保护作用进行了综述.
웅격소구유엄범적생물학효응.웅격소급기수체엄범존재우심뇌혈관계통,병재결혈성뇌혈관병(ischemic cerebrovascular disease,ICVD)발생화발전적다개배절발휘착중요적보호작용.제삼여조절ICVD발병적위험인소,여동맥죽양경화、혈지이상、고혈압、응혈-섬용이상、비반、당뇨병등외,웅격소환구유신경보호작용.문장대웅격소재ICVD중적보호작용진행료종술.
Androgen has broad biological effects. Androgen and its receptor exist widely in the cardio-cerebrovascular system and play an important protective effect in the multiple aspects of the occurrence and development of ischemic cerebrovascular disease (ICVD). In addition to involving in regulating the risk factors for ICVD, such as atherosclerosis,dyslipidemia, hypertension, coagulation-fibrinolysis abnormalities, obesity, and diabetes, androgen also has neuroprotective effect. This article reviews the protective effect of androgen in ICVD.