CAJ | 학술논문

目的应用共焦激光角膜显微镜观察干燥综合征(Sj(o)gren syndrome,SS)患者角膜上皮及上皮基底层下神经的组织学改变.方法用共焦激光角膜显微镜对22例干燥综合征患者进行检查,同时选择年龄与性别与之相匹配的15名正常人作对照,并对两组人员行角膜敏感度检查.结果 (1)SS组与正常人对照组比较角膜敏感度下降(P=0.000). (2)两组间角膜上皮基底细胞密度的变化无统计学意义(P>0.05). (3)关于角膜卜皮基底层下神经纤维的改变:SS组神经数量比正常对照组增加(P=0.000);神经密度比正常对照组增加(P=0.046);神经弯曲度比正常对照组增加(P=0.001);神经分支数也比正常对照组增加(P=0.040). (4)神经弯曲度与角膜敏感度呈负相关(r=0.304,P=0.029).结论 SS患者的角膜上皮、上皮基底层下神经纤维以及角膜敏感度均发生了一系列改变.
목적 응용공초격광각막현미경관찰간조종합정(Sj(o)gren syndrome,SS)환자각막상피급상피기저층하신경적조직학개변.방법 용공초격광각막현미경대22례간조종합정환자진행검사,동시선택년령여성별여지상필배적15명정상인작대조,병대량조인원행각막민감도검사.결과 (1)SS조여정상인대조조비교각막민감도하강(P=0.000). (2)량조간각막상피기저세포밀도적변화무통계학의의(P>0.05). (3)관우각막복피기저층하신경섬유적개변:SS조신경수량비정상대조조증가(P=0.000);신경밀도비정상대조조증가(P=0.046);신경만곡도비정상대조조증가(P=0.001);신경분지수야비정상대조조증가(P=0.040). (4)신경만곡도여각막민감도정부상관(r=0.304,P=0.029).결론 SS환자적각막상피、상피기저층하신경섬유이급각막민감도균발생료일계렬개변.
Objective To investigate the alteratiun of corneal epithelium and nerves in patients with Sj(o)gren syndrome (SS)by laser ennfocal microscopy.Method 22 patients and 15 healthy volunteers were investigated by laser eonfoeal microscopy,and measure their corneal sensitivity.Result (1)SS patients showed a significant decrease in corneal sensitivity comparing with normal person(P=0.000).(2)The shape of the epithelial cells were irregular,and even erosion can be seen in SS patients.There were no significant difference between the tow groups (P>0.05)in the density of basal epithelial cell. (3)Compared with normal controls,a increased nerve number and branching appeared more frequently in SS patients (P=0.040).(4)A negative eorrelatiun was found between the tortuosity and corneal sensitivity (r=0.304,P=0.029)by using Person correlation analysis.Cenelusion Alternations have occurred on the patients' eumeal epithelium,nerves and sensitivity with SS.