CAJ | 학술논문

目的研究伴糖耐量异常(IGT)的高血压患者的胰岛素抵抗及胰岛β细胞功能变化.方法选取不同糖耐量的高血压患者84例,测量血压、身高、体质量、腰围、臀围、空腹血糖、空腹胰岛素等参数,计算体重指数、腰/臀围比值、胰岛素敏感指数、胰岛素抵抗指数(HOMA-IR)和胰岛素分泌指数(HOMA-IS、FBCI),在不同糖耐量组间进行统计学比较.结果 IGT组与2型糖尿病(T2DM)组相似,体重指数、腰/臀围比值均高于正常糖耐量(NGT)组(P<0.05,P<0.01);胰岛素敏感指数、HOMA-IS和FBCI IGT组低于NGT组、T2DM组低于IGT组(P<0.05,P<0.01);T2DM组和IGT组的HOMA-IR高于NGT组(P<0.05).结论合并高血压糖耐量异常或糖尿病患者存在更高的胰岛素抵抗,同时胰岛素敏感性和胰岛β细胞功能下降,表现体质量较重,腰/臀围比值较高.
목적 연구반당내량이상(IGT)적고혈압환자적이도소저항급이도β세포공능변화.방법 선취불동당내량적고혈압환자84례,측량혈압、신고、체질량、요위、둔위、공복혈당、공복이도소등삼수,계산체중지수、요/둔위비치、이도소민감지수、이도소저항지수(HOMA-IR)화이도소분비지수(HOMA-IS、FBCI),재불동당내량조간진행통계학비교.결과 IGT조여2형당뇨병(T2DM)조상사,체중지수、요/둔위비치균고우정상당내량(NGT)조(P<0.05,P<0.01);이도소민감지수、HOMA-IS화FBCI IGT조저우NGT조、T2DM조저우IGT조(P<0.05,P<0.01);T2DM조화IGT조적HOMA-IR고우NGT조(P<0.05).결론 합병고혈압당내량이상혹당뇨병환자존재경고적이도소저항,동시이도소민감성화이도β세포공능하강,표현체질량교중,요/둔위비치교고.
Objective To study change of insulin resistance and beta-cell function of the patients in hyper-tension with normal glucose tolerance(NGT) to phthogonesis of type 2 diabetes mellitus(T2DM). Methods 84 pa-tients with hypertension were divided into NGT group,and groups of impaired glucose tolerance(IGT) with groups of T2DM. The blood pressure, height, weight, waist circumference, hip circumference, high-density lipoproteins (HDL-C)and total cholesterol(TC) ,fasting plasma glucose(FPG) and fasting plasma insulin(FINS) were measured to deter-mine the body mass index(BMI) ,waist/hip ratio(WHR) ,insulin secretion function[ including Homa β-cell function index(HBCI) and fasting β-cell function index(FBCI)] and insulin resistance level [ including Homa model insulin resistance index(IR) and insulin action index(IAI)] ,statistic comparison were measured between the groups of dif-ferent glucose tolerances. Results The BMI, WHR, diastolic blood pressure ( DBP), TC in IGT group and T2DM group were bigger or higher than those in NGT group ( P<0.05, P<0.01 ), the IAI, HOMA-IS and FBCI in T2DM group were lower than those in NGT group with these in NGT group were lower than those in NGT group( P<0.05 ,P<0.01 ). The HOMA-IR in IGT group and T2DM group were higher than those in NGT group with these in T2DM group were higher than those in NGT group. Conclusion T2DM group and IGT group had more insulin resistance level,sensitivity of insulin and islet β-cell function decrease than those in IGT group,the IGT group and T2DM group are analogous at the body weight is heavier, with waist/hips ratio, triglyceride level and DBP are higher than those in the NGT group in clinic.