CAJ | 학술논문

目的探讨凋亡抑制蛋白Livin在小细胞肺癌(SCLC)组织中的表达及其与p53之间的关系.方法采用免疫组织化学染色S-P法检测Livin和p53在30例SCLC组织和16例癌旁正常肺组织中的表达情况.结果 Livin在SCLC组织中的表达率为56.67%,明显高于癌旁正常肺组织的12.50%(P＜0.01). Livin的表达与患者年龄、性别、肿瘤的TNM分期、淋巴结转移和肿瘤大小均无关(P＞0.05).30例SCLC组织中有14例(46.67%)p53表达,而16例癌旁正常肺组织中无p53表达,两者之间差异有统计学意义(P＜0.01).在SCLC组织中Livin与p53表达呈正相关(P＜0.01).结论 Livin在SCLC组织中异常表达,有望成为SCLC诊断和基因治疗的新靶点.Livin与p53的异常表达可能在SCLC癌变中起协调作用.
목적 탐토조망억제단백Livin재소세포폐암(SCLC)조직중적표체급기여p53지간적관계.방법 채용면역조직화학염색S-P법검측Livin화p53재30례SCLC조직화16례암방정상폐조직중적표체정황.결과 Livin재SCLC조직중적표체솔위56.67%,명현고우암방정상폐조직적12.50%(P＜0.01). Livin적표체여환자년령、성별、종류적TNM분기、림파결전이화종류대소균무관(P＞0.05).30례SCLC조직중유14례(46.67%)p53표체,이16례암방정상폐조직중무p53표체,량자지간차이유통계학의의(P＜0.01).재SCLC조직중Livin여p53표체정정상관(P＜0.01).결론 Livin재SCLC조직중이상표체,유망성위SCLC진단화기인치료적신파점.Livin여p53적이상표체가능재SCLC암변중기협조작용.
Objective To study the expression of Livin and its relalionship with expression of p53 in small cell hmg cancer(SCLC).Methods Immunohistochemical S-P method was used to detect the ex-pression of Livin and p53 protein in 30 SCLC tissues and 16 para-cancerous lung tissues.Results Livin protein was expressed in 17 of 30 SCLC tissues(56.67%),but Livin protein showed low levels in para-can-cerous lung tissues(12.50%),P＜0.01.There was no significant correlalion between positive Livin protein expression and age,sex,TNM staging,lymph node metastasis and lumor diameter(P＞0.05).p53 protein was expressed in 14 of 30 SCLC tissues(46.67%),but p53 protein was no expressed in para-caneerous lung tissues,P＜0.01.The expression of Livin protein was positively related to the expression of p53 protein(P＜0.01).Conclusions The aberrant expression of Livin may be a new target for diagnosis and gene treatment of SCLC.The aberrant expression of Livin and p53 may play synergetic role in process of carcinogenesis of SCLC.