CAJ | 학술논문

目的探讨便携式有机磷快速检测仪(简称检测仪)治疗急性有机磷农药中毒(AOPP)的临床价值及意义.方法将西安交通大学医学院第一附属医院急诊科2005年3月至2007年2月收治的90例急性农药(包括有机磷与非有机磷农药)中毒患者均用检测仪进行检测,其中确诊为急性有机磷农药中毒(AOPP)的66例患者为检测组;2005年3月～2006年2月间收治的确诊为AOPP患者60例为埘照组.明确检测仪快速准确诊断情况,通过t检验将两组的胆碱酯酶(cholinesterase,ChE)活力在24 h,48 h,72 h,96 h,120 h,144 h和出院时的恢复效果进行比较.结果检测仪町以帮助医生快速明确毒物性质(是否为有机磷中毒);两组轻度中毒患者血清胆碱酯酶(cholinesterase,ChE)活性恢复时间比较差异无统计学意义(P＞0.05).检测组中重度患者血清ChE活力在48 h,72 h,96 h,120 h及出院时与对照组比较都有显著升高,差异有统计学意义(P＜0.05).结论检测仪可以帮助医生快速明确毒物性质;洗胃是否彻底以及是否需要再次洗胃有了客观依据;监测下洗胃疗效优于对照组;故该检测仪值得临床推广应用.
목적 탐토편휴식유궤린쾌속검측의(간칭검측의)치료급성유궤린농약중독(AOPP)적림상개치급의의.방법 장서안교통대학의학원제일부속의원급진과2005년3월지2007년2월수치적90례급성농약(포괄유궤린여비유궤린농약)중독환자균용검측의진행검측,기중학진위급성유궤린농약중독(AOPP)적66례환자위검측조;2005년3월～2006년2월간수치적학진위AOPP환자60례위시조조.명학검측의쾌속준학진단정황,통과t검험장량조적담감지매(cholinesterase,ChE)활력재24 h,48 h,72 h,96 h,120 h,144 h화출원시적회복효과진행비교.결과 검측의정이방조의생쾌속명학독물성질(시부위유궤린중독);량조경도중독환자혈청담감지매(cholinesterase,ChE)활성회복시간비교차이무통계학의의(P＞0.05).검측조중중도환자혈청ChE활력재48 h,72 h,96 h,120 h급출원시여대조조비교도유현저승고,차이유통계학의의(P＜0.05).결론 검측의가이방조의생쾌속명학독물성질;세위시부철저이급시부수요재차세위유료객관의거;감측하세위료효우우대조조;고해검측의치득림상추엄응용.
Objective To investigate the clinical application of portable orgnaophosphorus pesticide fast de-tector (abbreviated as Detector). Method The Detector was used in 90 acute pesticide (including orgnaophos-phorus pesticide and non-orgnaophosphorus pesticide) poisoning patients, who were treated in the Emergency De-partment of the First Hospital of Xi' an Jiaotong University from March 2006 to February 2007. The monitored group consisted of 66 patients, who were diagnosed with acute organophosphorus pesticide poisoning (AOPP). The control group consisted of 60 patients, who were diagnosed with AOPP from March 2005 to February 2006. We i-dentified the rapid diagnosis circumstance of the Detector, and compared the cholinesterase activity recovery at 48 h,72 h,96 h, 120 h, 144 hours and discharge between the monitored group and control group by t-test. Results The Detector identified the nature of the toxin quickly (whether poisoned for organophosphate or not). There was no statistically difference in recovery time of ChE activity in the serum of patients with AOPP (mild poisoning)be-tween the control group and the monitored group (P＞ 0.05). While ChE activity in serum of patients with moder-ate and severe was significantly increased at 48 h,72 h,96 h, 120 h, 144 h and discharge when compared to the control group (P ＜ 0.05). Conclusions The Detector can help doctors quickly identify the nature of the toxin.The result is used to judge whether a gastric lavage is effective.