CAJ | 학술논문

目的探讨脑源性神经营养因子(BDNF)在抑郁发作自杀未遂者中的可能作用.方法对抑郁发作自杀未遂患者(自杀未遂组,23例)和抑郁发作无自杀行为患者(无自杀组,24例)采用汉密尔顿抑郁量表(24项,HAMD24)、Beck绝望量表(BHS)和自杀意念自评量表(SIOSS)评定抑郁严重程度、绝望程度及自杀意图的强烈程度;采用酶联免疫吸附法测定其血清BDNF浓度,并与正常对照者(对照组,30名)比较;对自杀未遂组的血清BDNF浓度与各相关因素进行Pearson相关分析.结果 (1)自杀未遂组的HAMD24[(37.8±8.7)分]、BHS[(13.0±3.8)分]及SIOSS评分[(18.1±3.9)分]均高于无自杀组[分别为(26.0±6.0)分、(7.5±4.3)分、(12.0±4.0)分;P<0.01].(2)自杀未遂组的BDNF平均浓度[(57 ±16)ng/L]低于无自杀组[(75 ±28)ng/L;P<0.05],无自杀组的BDNF平均浓度亦低于正常对照组[(111±39)ng/L;P<0.01].(3)自杀未遂组的血清BDNF浓度与抑郁发作的病程(r=-0.541)、BHS总分(r=-0.494)、SIOSS总分(r=-0.754)呈负相关(P<0.01-0.05).结论低水平的BDNF可能是抑郁发作自杀未遂的一个危险因素.
목적 탐토뇌원성신경영양인자(BDNF)재억욱발작자살미수자중적가능작용.방법 대억욱발작자살미수환자(자살미수조,23례)화억욱발작무자살행위환자(무자살조,24례)채용한밀이돈억욱량표(24항,HAMD24)、Beck절망량표(BHS)화자살의념자평량표(SIOSS)평정억욱엄중정도、절망정도급자살의도적강렬정도;채용매련면역흡부법측정기혈청BDNF농도,병여정상대조자(대조조,30명)비교;대자살미수조적혈청BDNF농도여각상관인소진행Pearson상관분석.결과 (1)자살미수조적HAMD24[(37.8±8.7)분]、BHS[(13.0±3.8)분]급SIOSS평분[(18.1±3.9)분]균고우무자살조[분별위(26.0±6.0)분、(7.5±4.3)분、(12.0±4.0)분;P<0.01].(2)자살미수조적BDNF평균농도[(57 ±16)ng/L]저우무자살조[(75 ±28)ng/L;P<0.05],무자살조적BDNF평균농도역저우정상대조조[(111±39)ng/L;P<0.01].(3)자살미수조적혈청BDNF농도여억욱발작적병정(r=-0.541)、BHS총분(r=-0.494)、SIOSS총분(r=-0.754)정부상관(P<0.01-0.05).결론 저수평적BDNF가능시억욱발작자살미수적일개위험인소.
Objective To investigate the possible role of brain-derived neurotrophic factor(BDNF)in the pathophysiology of attempted suicide in depressive episode patients.Methods The subjects were 23 depressive episode patients who had recently attempted suicide.24 depressive episode patients without suicide attempt.and 30 sex-age-and education matched healthy controls.The Hamihon Depression Rating Scale-24 items(HAMD24),Beck Helpless Rating Scale(BHS)and Self-rating Idea of Suicide Scale (SIOSS)was used to evaluate the severitv of symptoms.The seruln level of BDNF was detected with sandwich ELISA.Pearson correlation coefficients wag used to measure the correlations between serum BDNF and the related illness variables.Results There were significant difierences in the serum level of BDNF between patients with attempted suicide,pailents without suicide attempt and normal controls(F=21.927,P＜0.05).Post hoc analysis showed the serum BDNF levels in patients with attempted suicide [(57 ±16)ng/L]were lower than that in patients without[(75±28)ns/L;P＜0.05],and were lower in patients without suicide attempt[(75 ±28)ng/L]than that in normal controls[(111 ±39)ng/L;P＜0.01].In patients with attempted suicide,the serum BDNF was negatively correlated to the duration of depressive episode(r=-0.541,P=0.008),the mean BHS score(r=-0.494,P=0.017)and the mean SIOSSscore(r=-0.754.P=0.000).Conclusion The results suggest that the decreased serum brain-derived neurotrophic factor is related to the pathophysiology of attempted suicide in depressive episode patients.