CAJ | 학술논문

目的调查南京地区帕金森病(PD)患者及50岁以上的对照者抑郁状态的发生率,分析PD合并抑郁状态(PDD)的特点及影响因素.方法采用抑郁自评量表(SDS)、汉密尔顿抑郁量表(HAMD)对126例PD患者进行抑郁状态调查,统计分析PDD的发生率及其特点和相关影响因素,并进行HAMD因子分析.同时选取50岁以上无明显躯体疾病的体检者124名作为对照组.结果 PDD的发生率为48.4％(61/126),包括轻度抑郁15.1％(19/126),中度抑郁27.8％(35/126),重度抑郁5.6％(7/126)；对照组抑郁状态发生率为9.7％ (12/124),包括轻度抑郁5.7％ (7/124),中度抑郁2.4％ (3/124),重度抑郁1.6％ (2/124)；两组相比差异有统计学意义(x2 =45.36,P＜0.01).单因素及Logistic回归分析显示病程越长,统一帕金森病评分量表Ⅲ得分越高,H-Y分级越大则PDD的发生率越高.HAMD因子分析的结果显示,PDD患者在认知障碍、迟缓、躯体焦虑、睡眠障碍等方面比对照抑郁组得分明显增高.结论抑郁状态在南京地区PD患者中较常见,以中度抑郁为主.与PD的病程、运动障碍严重程度及H-Y分级相关.
목적 조사남경지구파금삼병(PD)환자급50세이상적대조자억욱상태적발생솔,분석PD합병억욱상태(PDD)적특점급영향인소.방법 채용억욱자평량표(SDS)、한밀이돈억욱량표(HAMD)대126례PD환자진행억욱상태조사,통계분석PDD적발생솔급기특점화상관영향인소,병진행HAMD인자분석.동시선취50세이상무명현구체질병적체검자124명작위대조조.결과 PDD적발생솔위48.4％(61/126),포괄경도억욱15.1％(19/126),중도억욱27.8％(35/126),중도억욱5.6％(7/126)；대조조억욱상태발생솔위9.7％ (12/124),포괄경도억욱5.7％ (7/124),중도억욱2.4％ (3/124),중도억욱1.6％ (2/124)；량조상비차이유통계학의의(x2 =45.36,P＜0.01).단인소급Logistic회귀분석현시병정월장,통일파금삼병평분량표Ⅲ득분월고,H-Y분급월대칙PDD적발생솔월고.HAMD인자분석적결과현시,PDD환자재인지장애、지완、구체초필、수면장애등방면비대조억욱조득분명현증고.결론 억욱상태재남경지구PD환자중교상견,이중도억욱위주.여PD적병정、운동장애엄중정도급H-Y분급상관.
Objective To determine the frequency of depression in patients with Parkinson' s disease(PD) and healthy controls over 50 years of age and to analyze the characteristics and influencing factors of PD with depression(PDD) in Nanjing.Methods One hundred and twenty-six PD patients were diagnosed and assessed using Self-rating Depression Scale (SDS) and Hamilton Depression Scale (HAMD).The frequency,characteristics and influencing factors of depression were statistically analyzed,and the factor analysis of HAMD was carried out.Also,one hundred and twenty-four healthy subjects over the age of 50 were selected as the control group.Ressults The incidence of depression in PD group was 48.4％ ( 61/126):15.1％ (19/126) for mild depression,27.8％ (35/126) for moderate depression,5.6％ (7/126) for severe depression.The incidence of depression in the control group was 9.7％ (12/124):5.7％ (7/124) for mild depression,2.4％ (3/124) for moderate depression,1.6％ (2/124) for severe depression.There was a significant difference between these two groups( x2 =45.36,P ＜ 0.01 ).Univariate and Logistic regression analysis revealed that a high frequency of depression occurred in patients with long PD duration,high H-Y stage and UPDRS Ⅲ.According to each factor analysis of HAMD,the scores of cognitive impairment,tardiness,anxiety and sleep disturbances of the PD patients with depressive syndromes were higher than that of the control group.Conclusion Depression is a relatively common complication of PD in Nanjing which is associated with long PD duration,severity of motor disturbances and increasing H-Y stage.