中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
CHINESE JOURNAL OF LABORATORY MEDICINE
2012年
7期
579-584
,共6页
多态性,单核苷酸%候选基因%全基因组关联研究%外显子测序%临床应用
多態性,單覈苷痠%候選基因%全基因組關聯研究%外顯子測序%臨床應用
다태성,단핵감산%후선기인%전기인조관련연구%외현자측서%림상응용
Single nucleotide polymorphisms%Candidate gene%Genome-wide association studies%Exome sequencing%Clinical application
单核苷酸多态性(SNP)是人类基因组中最为常见的一类遗传变异,依据其发展起来的候选基因策略、全基因组关联研究及外显子组测序等已经在鉴定肿瘤易感性方面取得了重大成就.近年来,随着高通量技术手段的发展和应用,SNP在阐述肿瘤发生的作用机制,肿瘤的预防、诊断乃至靶向治疗中都有重要的作用.
單覈苷痠多態性(SNP)是人類基因組中最為常見的一類遺傳變異,依據其髮展起來的候選基因策略、全基因組關聯研究及外顯子組測序等已經在鑒定腫瘤易感性方麵取得瞭重大成就.近年來,隨著高通量技術手段的髮展和應用,SNP在闡述腫瘤髮生的作用機製,腫瘤的預防、診斷迺至靶嚮治療中都有重要的作用.
단핵감산다태성(SNP)시인류기인조중최위상견적일류유전변이,의거기발전기래적후선기인책략、전기인조관련연구급외현자조측서등이경재감정종류역감성방면취득료중대성취.근년래,수착고통량기술수단적발전화응용,SNP재천술종류발생적작용궤제,종류적예방、진단내지파향치료중도유중요적작용.
Single nueleotide polymorphisms (SNPs) are the most common genetic variants in human genome.Candidate gene,genome-wide association studies (GWASs) and exome sequencing which base on SNPs have made a great progress in identifying cancer susceptibility.The development and application of high resolutions in SNPs has played an important role in clarifying the mechanism,prevention,diagnosis and targeted therapy in cancers.
