CAJ | 학술논문

目的观察维生素C与维生素E联合治疗对糖耐量受损(IGT)患者糖代谢的影响. 方法以口服葡萄糖耐量试验(OGTT)筛查IGT患者159例,随机分成治疗组和对照组,治疗组予口服维生素C 500 mg/d及维生素E 200 mg/d,6个月;对照组不进行任何治疗.分别于治疗前后检测血糖(PG)及胰岛素(Ins),用稳态模型评价胰岛素抵抗指数(HOMA-IR)及胰岛细胞分泌功能指数(HOMA-β). 结果治疗组FPG、Ins及HOMA-IR较试验前及对照组均明显下降,HOMA-β无明显变化.对照组试验前后各项指标无明显变化.试验结束时,对照组有3例转为糖尿病(DM),占3.8%,治疗组无DM发生.经χ2检验两组DM的发生率差异无显著意义(χ2=3.8,P>0.05). 结论维生素C与维生素E联合应用可以改善IGT患者的糖代谢,减轻其IR.
목적 관찰유생소C여유생소E연합치료대당내량수손(IGT)환자당대사적영향. 방법이구복포도당내량시험(OGTT)사사IGT환자159례,수궤분성치료조화대조조,치료조여구복유생소C 500 mg/d급유생소E 200 mg/d,6개월;대조조불진행임하치료.분별우치료전후검측혈당(PG)급이도소(Ins),용은태모형평개이도소저항지수(HOMA-IR)급이도세포분비공능지수(HOMA-β). 결과치료조FPG、Ins급HOMA-IR교시험전급대조조균명현하강,HOMA-β무명현변화.대조조시험전후각항지표무명현변화.시험결속시,대조조유3례전위당뇨병(DM),점3.8%,치료조무DM발생.경χ2검험량조DM적발생솔차이무현저의의(χ2=3.8,P>0.05). 결론유생소C여유생소E연합응용가이개선IGT환자적당대사,감경기IR.
Objective To observe the effects of vitamin(Vit) C and vit E combination therapy on glucose metabolism in impaired glucose tolerance (IGT) patients Methods 159 patients with IGT [fasting plasma glucose (FPG)<7 0 mmol/L and 2 h plasma glucose (PG2 h)≥7 8 mmol/L<11 1 mmol/L] were diagnosed by standard oral glucose tolerance test (OGTT) The patients were randomized into treatment(T, n =81) and control(C, n =78) groups The T group were treated with vit C (500 mg/d) and vit E (200 mg/d) for 6 months The C group had not any treatment The FPG and insulin were measured The insulin resistance (HOMA IR) and β cell function (HOMA β) were evaluated by the homeostasis model Results FPG, insulin and HOMA IR were significantly reduced in T group vs C group of IGT patients Significant difference was not noted in HOMA β between the T and C groups Three new diabetic patients appeared in C group (3 8%) and none of diabetes in T group at the end of the study, P >0 05 Conclusions Conclusions vit C vit E combination therapy can improve glucose metabolism and alleviate insulin resistance in the IGT patients