中国新药杂志
中國新藥雜誌
중국신약잡지
CHINESE NEW DRUGS JOURNAL
2007年
22期
1882-1884
,共3页
顶空气相色谱法%抗癫痫药物%左乙拉西坦%有机溶剂残留量
頂空氣相色譜法%抗癲癇藥物%左乙拉西坦%有機溶劑殘留量
정공기상색보법%항전간약물%좌을랍서탄%유궤용제잔류량
目的:建立左乙拉西坦中有机溶剂残留量的顶空气相色谱分析方法.方法:选用大口径HP-快速GC残留溶剂柱为分离柱,FID检测器,外标法进行定量,并对分离条件、顶空平衡温度、平衡时间对残留有机溶剂测定的影响进行了研究.结果:二氯甲烷、乙酸乙酯、甲苯的线性范围分别为0.133～1.326 μg·mL-1(r=0.999 7),4.330～43.296 μg·mL-1(r=1.000 0),0.009～0.087 μg·mL-1(r=0.999 7);平均回收率范围99.70%～102.46%,精密度RSD(n=6)为1.79%～3.05%;检测限分别为0.008,0.005,0.001 μg·mL-1.结论:该方法快速、灵敏、准确.
目的:建立左乙拉西坦中有機溶劑殘留量的頂空氣相色譜分析方法.方法:選用大口徑HP-快速GC殘留溶劑柱為分離柱,FID檢測器,外標法進行定量,併對分離條件、頂空平衡溫度、平衡時間對殘留有機溶劑測定的影響進行瞭研究.結果:二氯甲烷、乙痠乙酯、甲苯的線性範圍分彆為0.133～1.326 μg·mL-1(r=0.999 7),4.330～43.296 μg·mL-1(r=1.000 0),0.009～0.087 μg·mL-1(r=0.999 7);平均迴收率範圍99.70%～102.46%,精密度RSD(n=6)為1.79%～3.05%;檢測限分彆為0.008,0.005,0.001 μg·mL-1.結論:該方法快速、靈敏、準確.
목적:건립좌을랍서탄중유궤용제잔류량적정공기상색보분석방법.방법:선용대구경HP-쾌속GC잔류용제주위분리주,FID검측기,외표법진행정량,병대분리조건、정공평형온도、평형시간대잔류유궤용제측정적영향진행료연구.결과:이록갑완、을산을지、갑분적선성범위분별위0.133～1.326 μg·mL-1(r=0.999 7),4.330～43.296 μg·mL-1(r=1.000 0),0.009～0.087 μg·mL-1(r=0.999 7);평균회수솔범위99.70%～102.46%,정밀도RSD(n=6)위1.79%～3.05%;검측한분별위0.008,0.005,0.001 μg·mL-1.결론:해방법쾌속、령민、준학.
