国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2011年
4期
238-240
,共3页
乳腺肿瘤%化学疗法,辅助%Ki-67抗原%环氧合酶2%正电子发射断层显像术%体层摄影术,X线计算机
乳腺腫瘤%化學療法,輔助%Ki-67抗原%環氧閤酶2%正電子髮射斷層顯像術%體層攝影術,X線計算機
유선종류%화학요법,보조%Ki-67항원%배양합매2%정전자발사단층현상술%체층섭영술,X선계산궤
Breast neoplasms%Chemotherapy,adjuvant%Ki-67 antigen%Cycloocygenase 2%Positronemission tomography%Tomography,X-ray computed
目的 研究乳腺癌新辅助化疗过程中18F-FDG PET-CT的病灶最大标准化摄取值(SUVmax)的变化与其化疗前Ki-67(一种增殖细胞核抗原)、环氧合酶2(COX-2)表达的相关性.方法 初治乳腺癌患者19例,在新辅助化疗前、第1疗程结束后及第2疗程结束后分别行18F-FDG PET-CT,并计算病灶的SUVmax变化率,在新辅助化疗前取患者乳腺肿瘤组织标本进行Ki-67、COX-2免疫组化检查,并比较不同Ki-67和COX-2表达组之间的SUVmax变化率.结果 新辅助化疗前、第1疗程及第2疗程结束后的SUVmax变化率在化疗前Ki-67、COX-2不同表达组之间差异均无统计学意义.结论 化疗前Ki-67、COX-2的表达情况无法充分解释病灶在新辅助化疗过程中18F-FDG的摄取变化,而其最有可能的解释是细胞之间复杂的能源需求与肿瘤微环境的相互作用.
目的 研究乳腺癌新輔助化療過程中18F-FDG PET-CT的病竈最大標準化攝取值(SUVmax)的變化與其化療前Ki-67(一種增殖細胞覈抗原)、環氧閤酶2(COX-2)錶達的相關性.方法 初治乳腺癌患者19例,在新輔助化療前、第1療程結束後及第2療程結束後分彆行18F-FDG PET-CT,併計算病竈的SUVmax變化率,在新輔助化療前取患者乳腺腫瘤組織標本進行Ki-67、COX-2免疫組化檢查,併比較不同Ki-67和COX-2錶達組之間的SUVmax變化率.結果 新輔助化療前、第1療程及第2療程結束後的SUVmax變化率在化療前Ki-67、COX-2不同錶達組之間差異均無統計學意義.結論 化療前Ki-67、COX-2的錶達情況無法充分解釋病竈在新輔助化療過程中18F-FDG的攝取變化,而其最有可能的解釋是細胞之間複雜的能源需求與腫瘤微環境的相互作用.
목적 연구유선암신보조화료과정중18F-FDG PET-CT적병조최대표준화섭취치(SUVmax)적변화여기화료전Ki-67(일충증식세포핵항원)、배양합매2(COX-2)표체적상관성.방법 초치유선암환자19례,재신보조화료전、제1료정결속후급제2료정결속후분별행18F-FDG PET-CT,병계산병조적SUVmax변화솔,재신보조화료전취환자유선종류조직표본진행Ki-67、COX-2면역조화검사,병비교불동Ki-67화COX-2표체조지간적SUVmax변화솔.결과 신보조화료전、제1료정급제2료정결속후적SUVmax변화솔재화료전Ki-67、COX-2불동표체조지간차이균무통계학의의.결론 화료전Ki-67、COX-2적표체정황무법충분해석병조재신보조화료과정중18F-FDG적섭취변화,이기최유가능적해석시세포지간복잡적능원수구여종류미배경적상호작용.
Objective To study the expression of Ki-67 (a kind of proliferation cell nuclear antigen),cyclooxygenase-2 (COX-2) in breast cancer before neoadjuvant chemotherapy,and its correlation with the changes of maximum standarded uptake value (SUVmax).Methods In a prospertive trial,18F-FDG PET-CT were performed in 19 women with primary breast cancer before and after the first and second cycle of neoadjuvant chemotherapy respectively,the changes of SUVmax were computered.Divided the patients into different groups according to the Ki-67 and COX-2 expression,then compared the rate of change of SUVmax in different groups.Results There was no correlation between the changes of SUVmax after chemotherapy and the expression of Ki-67,COX-2 before neoadjuvant chemotherapy.Conclusions The expression of Ki-67 and COX-2 before neoadjuvant chemotherapy were unable to sufficiently explain the changes of 18F-FDG uptake during the chemotherapy process.The metabolic changes were most likely explained by a complex interaction between cellular energy demand and tumoral microenvironment.