中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2011年
3期
221-224
,共4页
青光眼%视网膜神经纤维层%GDxVCC
青光眼%視網膜神經纖維層%GDxVCC
청광안%시망막신경섬유층%GDxVCC
Glaucoma%RNFL%GDxVCC
目的 比较正常人和不同程度青光眼患者GDxVCC系统检测RNFL参数的不同,评价GDx各参数的敏感性、特异性,探讨GDxVCC系统检测视网膜神经纤维层在青光眼早期诊断中的价值.方法 对35例(35只眼)原发性开角型青光眼、33例(33只眼)慢性闭角型青光眼、27例(27只眼)急性闭角型青光眼以及年龄相匹配的36人(36只眼)正常人进行GDxVCC系统和静态视野检查.GDxVCC系统检查,视盘周围视网膜神经纤维层(retinal nerve fiber layer,RNFL)任一参数与系统内所附中国正常人数据库对比概率＜5%或NFI＞30或视网膜神经纤维标准偏差图上连续有10个超级像素概率＜5%定义为具有青光眼性视网膜神经纤维层结构损害,并判断为青光眼.结果 22只正常眼被判断为非青光眼(61.1%),82只青光眼被判断为青光眼(86.3%),RNFL参数椭圆平均值、上方平均值、下方平均值、TSNIT标准偏差、神经纤维指数,标准偏差图诊断青光眼的敏感性分别为48.4%、56.8%、48.4%、50.5%、62.1%,特异性分别为97.2%、100%、97.2%、94.4%、97.2%、61.1%.GDxVCC系统诊断早期、中期、晚期青光眼的敏感性分别为77.36%、95.83%、100%.结论 GDxVCC系统诊断早期青光眼的敏感性和特异性均高,而且RNFL参数中神经纤维指数的敏感性最高.
目的 比較正常人和不同程度青光眼患者GDxVCC繫統檢測RNFL參數的不同,評價GDx各參數的敏感性、特異性,探討GDxVCC繫統檢測視網膜神經纖維層在青光眼早期診斷中的價值.方法 對35例(35隻眼)原髮性開角型青光眼、33例(33隻眼)慢性閉角型青光眼、27例(27隻眼)急性閉角型青光眼以及年齡相匹配的36人(36隻眼)正常人進行GDxVCC繫統和靜態視野檢查.GDxVCC繫統檢查,視盤週圍視網膜神經纖維層(retinal nerve fiber layer,RNFL)任一參數與繫統內所附中國正常人數據庫對比概率＜5%或NFI＞30或視網膜神經纖維標準偏差圖上連續有10箇超級像素概率＜5%定義為具有青光眼性視網膜神經纖維層結構損害,併判斷為青光眼.結果 22隻正常眼被判斷為非青光眼(61.1%),82隻青光眼被判斷為青光眼(86.3%),RNFL參數橢圓平均值、上方平均值、下方平均值、TSNIT標準偏差、神經纖維指數,標準偏差圖診斷青光眼的敏感性分彆為48.4%、56.8%、48.4%、50.5%、62.1%,特異性分彆為97.2%、100%、97.2%、94.4%、97.2%、61.1%.GDxVCC繫統診斷早期、中期、晚期青光眼的敏感性分彆為77.36%、95.83%、100%.結論 GDxVCC繫統診斷早期青光眼的敏感性和特異性均高,而且RNFL參數中神經纖維指數的敏感性最高.
목적 비교정상인화불동정도청광안환자GDxVCC계통검측RNFL삼수적불동,평개GDx각삼수적민감성、특이성,탐토GDxVCC계통검측시망막신경섬유층재청광안조기진단중적개치.방법 대35례(35지안)원발성개각형청광안、33례(33지안)만성폐각형청광안、27례(27지안)급성폐각형청광안이급년령상필배적36인(36지안)정상인진행GDxVCC계통화정태시야검사.GDxVCC계통검사,시반주위시망막신경섬유층(retinal nerve fiber layer,RNFL)임일삼수여계통내소부중국정상인수거고대비개솔＜5%혹NFI＞30혹시망막신경섬유표준편차도상련속유10개초급상소개솔＜5%정의위구유청광안성시망막신경섬유층결구손해,병판단위청광안.결과 22지정상안피판단위비청광안(61.1%),82지청광안피판단위청광안(86.3%),RNFL삼수타원평균치、상방평균치、하방평균치、TSNIT표준편차、신경섬유지수,표준편차도진단청광안적민감성분별위48.4%、56.8%、48.4%、50.5%、62.1%,특이성분별위97.2%、100%、97.2%、94.4%、97.2%、61.1%.GDxVCC계통진단조기、중기、만기청광안적민감성분별위77.36%、95.83%、100%.결론 GDxVCC계통진단조기청광안적민감성화특이성균고,이차RNFL삼수중신경섬유지수적민감성최고.
Objective To evaluate the usefulness of the scanning laser polarimeter with variable corneal compensation (GDxVCC) for glaucoma detection in a Chinese population,and to investigate the retinal nerve fiber layer (RNFL) thickness difference between normal subjects and glaucoma patients.Methods Thirty-six eyes of 36 normal subjects,33 eyes of 33 primary chronic angle-closure glaucoma patients,27 eyes of 27 primary acute angle-closure glaucoma and 35 eyes of 35 primary open-angle glaucoma patients were studied.The glaucoma patients were age-matched with the normal.The thickness of retinal nerve fiber layer was measured with GDxVCC.An eye was diagnosed as glaucoma,ifone of the parameters showed P＜0.05 on the results of the examination reports including four TSNIT parameters (the average of TSNIT,superior,inferior,and TSNIT Std.Dev.),nerve fiber indicator (NFI) ＞ 30,and at least 10 consecutive defects of superpels showed in deviation map (P ＜0.05).Results Of 22 normal eyes (61.1%) were diagnosed as non-glaucoma and 82 glaucomatous eyes (86.3%) were diagnosed as glaucoma by GDxVCC.Sensitivity of the average of TSNIT,superior,inferior,TSNIT Std.Dev.,NFI and the deviation map were 48.4%,56.8%,48.4%,50.5%,62.1% respectively and specificity were 97.2%,100%,97.2%,94.4%,97.2% and 61.1% respectively.Sensitivity of detection early,moderate and progression glaucoma by GDxVCC were 77.36%,95.83%,100% respectively.Conclusions GDxVCC is a valuable technology to detect retinal nerve fiber layer defect in early glaucoma.It is shown that the NFI has highest sensitivity.
