中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2011年
12期
1000-1002
,共3页
朱幸沨%郑明峰%陈静瑜%何毅军%陈若%朱乾坤%叶书高%刘峰%陆荣国
硃倖沨%鄭明峰%陳靜瑜%何毅軍%陳若%硃乾坤%葉書高%劉峰%陸榮國
주행풍%정명봉%진정유%하의군%진약%주건곤%협서고%류봉%륙영국
氨溴索%慢性阻塞性肺疾病%手术后并发症%肺不张
氨溴索%慢性阻塞性肺疾病%手術後併髮癥%肺不張
안추색%만성조새성폐질병%수술후병발증%폐불장
Ambroxol%Pulmonary disease,chronic obstructive%Postoperative complications%Atelectasis
目的 评估氨溴索对老年慢性阻塞性肺疾病(COPD)患者开胸术后肺部并发症的预防作用.方法 纳入COPD开胸手术后患者(≥70岁)161例,分为两组,氨溴索组在围手术期间静脉应用氨溴索300 mg/d,连用6 d；对照组应用安慰剂.依据临床症状、影像学改变及血气分析诊断肺部并发症.结果 肺不张的发生率氨溴索组8.6％,安慰剂组达28.8％,差异有统计学意义(P＜0.05),与术前相比,氨溴索组术后血氧分压( PaO2)下降较安慰剂组明显(P＜0.05).所有患者未出现药物不良反应.结论 氨溴索可作为老年COPD患者预防开胸术后肺部并发症的药物.
目的 評估氨溴索對老年慢性阻塞性肺疾病(COPD)患者開胸術後肺部併髮癥的預防作用.方法 納入COPD開胸手術後患者(≥70歲)161例,分為兩組,氨溴索組在圍手術期間靜脈應用氨溴索300 mg/d,連用6 d；對照組應用安慰劑.依據臨床癥狀、影像學改變及血氣分析診斷肺部併髮癥.結果 肺不張的髮生率氨溴索組8.6％,安慰劑組達28.8％,差異有統計學意義(P＜0.05),與術前相比,氨溴索組術後血氧分壓( PaO2)下降較安慰劑組明顯(P＜0.05).所有患者未齣現藥物不良反應.結論 氨溴索可作為老年COPD患者預防開胸術後肺部併髮癥的藥物.
목적 평고안추색대노년만성조새성폐질병(COPD)환자개흉술후폐부병발증적예방작용.방법 납입COPD개흉수술후환자(≥70세)161례,분위량조,안추색조재위수술기간정맥응용안추색300 mg/d,련용6 d；대조조응용안위제.의거림상증상、영상학개변급혈기분석진단폐부병발증.결과 폐불장적발생솔안추색조8.6％,안위제조체28.8％,차이유통계학의의(P＜0.05),여술전상비,안추색조술후혈양분압( PaO2)하강교안위제조명현(P＜0.05).소유환자미출현약물불량반응.결론 안추색가작위노년COPD환자예방개흉술후폐부병발증적약물.
Objective To evaluate the effects of ambroxol on prevention of bronchopulmonary complications after thoracotomy in patients with chronic obstructive pulmonary disease(COPD).Methods Total 161 elderly patients aged ≥70 years with COPD undergoing thoracotomy were randomly allocated to two groups:ambroxol group (300 mg/d,6 d) and placebo group as control.Pulmonary complications were evaluated by clinical symptoms,radiographic changes,and blood gas analysis. Results The incidence rates of atelectasis were 8.6％ in ambroxol group and 28.8％ in placebo group,respectively.The PaO2 values after surgery in ambroxol group decreased more than in placebo group (P＜0.05) compared with the preoperative values.Side effects were not found in all patients.Conclusions Ambroxol should be considered as an alternative pharmacologic approach for the prevention of post-thoracotomy pulmonary complications in the elderly patients with COPD.
