国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2011年
8期
584-587
,共4页
刘训超%董德琼%杨渝浩%潘磊
劉訓超%董德瓊%楊渝浩%潘磊
류훈초%동덕경%양투호%반뢰
肺结核%趋化因子%γ干扰素诱导蛋白10%巨噬细胞炎症蛋白1α
肺結覈%趨化因子%γ榦擾素誘導蛋白10%巨噬細胞炎癥蛋白1α
폐결핵%추화인자%γ간우소유도단백10%거서세포염증단백1α
Lung tuberculosis%Chemokine%Interferon-γ inducible protein-10%Macrophage inflammatory protein-1α
目的 探讨趋化因子γ干扰素诱导蛋白10(IP-10)和巨噬细胞炎症蛋白1α(MIP-1α)在判断肺结核活动性中的临床意义.方法 回颐性分析活动性和非活动性肺结核患者各60例及40例正常健康人外周血清中IP-10和MIP-1α的水平.根据活动性及非活动性肺结核组IP-10和MIP-1α的检测值制作受试者工作特征(ROC)曲线,评价IP-10和MIP-1α判断肺结核活动性中的临床价值.结果 活动性肺结核组治疗前血清IP-10和MIP-1α的水平高于对照组和非活动性肺结核组(P值均＜0.01),对照组和非活动性肺结核组之间IP-10和MIP-1α的水平差异无统计学意义.ROC曲线分析结果显示,IP-10判断活动性肺结核的曲线下面积为0.887,敏感性和特异性分别是83.3%、90.0%;MIP-1α判断活动性肺结核的曲线下面积为0.931,敏感性和特异性分别为86.7%、83.3%;IP-10联合MIP-1α并列试验敏感性为93.3%.结论 IP-10和MIP-1α在活动性肺结核患者中显著增高,提示IP-10和MIP-1α可能参与了肺结核的发病,可望作为判断肺结核活动的临床参考指标;ROC曲线分析结果显示血清IP-10和MIP-1α对肺结核是否活动的判断均具较高价值,二者联合检测可提高敏感性.
目的 探討趨化因子γ榦擾素誘導蛋白10(IP-10)和巨噬細胞炎癥蛋白1α(MIP-1α)在判斷肺結覈活動性中的臨床意義.方法 迴頤性分析活動性和非活動性肺結覈患者各60例及40例正常健康人外週血清中IP-10和MIP-1α的水平.根據活動性及非活動性肺結覈組IP-10和MIP-1α的檢測值製作受試者工作特徵(ROC)麯線,評價IP-10和MIP-1α判斷肺結覈活動性中的臨床價值.結果 活動性肺結覈組治療前血清IP-10和MIP-1α的水平高于對照組和非活動性肺結覈組(P值均＜0.01),對照組和非活動性肺結覈組之間IP-10和MIP-1α的水平差異無統計學意義.ROC麯線分析結果顯示,IP-10判斷活動性肺結覈的麯線下麵積為0.887,敏感性和特異性分彆是83.3%、90.0%;MIP-1α判斷活動性肺結覈的麯線下麵積為0.931,敏感性和特異性分彆為86.7%、83.3%;IP-10聯閤MIP-1α併列試驗敏感性為93.3%.結論 IP-10和MIP-1α在活動性肺結覈患者中顯著增高,提示IP-10和MIP-1α可能參與瞭肺結覈的髮病,可望作為判斷肺結覈活動的臨床參攷指標;ROC麯線分析結果顯示血清IP-10和MIP-1α對肺結覈是否活動的判斷均具較高價值,二者聯閤檢測可提高敏感性.
목적 탐토추화인자γ간우소유도단백10(IP-10)화거서세포염증단백1α(MIP-1α)재판단폐결핵활동성중적림상의의.방법 회이성분석활동성화비활동성폐결핵환자각60례급40례정상건강인외주혈청중IP-10화MIP-1α적수평.근거활동성급비활동성폐결핵조IP-10화MIP-1α적검측치제작수시자공작특정(ROC)곡선,평개IP-10화MIP-1α판단폐결핵활동성중적림상개치.결과 활동성폐결핵조치료전혈청IP-10화MIP-1α적수평고우대조조화비활동성폐결핵조(P치균＜0.01),대조조화비활동성폐결핵조지간IP-10화MIP-1α적수평차이무통계학의의.ROC곡선분석결과현시,IP-10판단활동성폐결핵적곡선하면적위0.887,민감성화특이성분별시83.3%、90.0%;MIP-1α판단활동성폐결핵적곡선하면적위0.931,민감성화특이성분별위86.7%、83.3%;IP-10연합MIP-1α병렬시험민감성위93.3%.결론 IP-10화MIP-1α재활동성폐결핵환자중현저증고,제시IP-10화MIP-1α가능삼여료폐결핵적발병,가망작위판단폐결핵활동적림상삼고지표;ROC곡선분석결과현시혈청IP-10화MIP-1α대폐결핵시부활동적판단균구교고개치,이자연합검측가제고민감성.
Objective To explore the clinical significance of chemokine interferon-γ inducible protein-10 (IP-10) and macrophage inflammatory protein-1α (MIP-1α) in active pulmonary tuberculosis.Methods The serum levels of IP-10 and MIP-1α in 60 patients with active pulmonary tuberculosis, 60 patients with nonactive pulmonary tuberculosis, and 40 healthy persons were retrospectively analyzed. The clinical value of IP-10 and MIP-1α in the decision of active pulmonary tuberculosis was assessed by ROC curve. Results The serum levels of IP-10 and MIP-1α in patients with active pulmonary tuberculosis were higher than those in patients with nonactive pulmonary tuberculosis and healthy control (all P ＜0.01 ),while there was no statistical significance on the serum levels of IP-10 and MIP-1α between patients with nonactive pulmonary tuberculosis and healthy control. ROC curve analysis showed that the area under curve of IP-10 and MIP-1α was 0. 887 and 0. 931, the sensitivity and specificity of IP-10 for active pulmonary tuberculosis were 83.3% and 90.0%, and the sensitivity and specificity of MIP-1α for active pulmonary tuberculosis were 86.7% and 83.3%. The sensitivity of the parallel test of IP-10 and MIP-1α for active pulmonary tuberculosis was 93.3%. Conclusions The levels of IP-10 and MIP-1α in patients with active pulmonary tuberculosis significantly increase,which suggests that IP-10 and MIP-1α may be involved in the pathogenisis of pulmonary tuberculosis. ROC curve analysis shows that serum IP-10 and MIP-1α are new valuable parameters for the decision of active pulmonary tuberculosis, and the parallel test can increase the sensitivity.
