CAJ | 학술논문

目的比较三种不同手术方式治疗翼状胬肉的疗效.方法对210例(230眼)翼状胬肉患者随机分别采用单纯手术切除(A组,共75眼)、手术切除联合自体结膜瓣遮盖(B组.共77眼)、手术切除联合自体角膜缘干细胞移植(C组,共78眼).术后观察角膜创面的愈合时间及翼状胬肉的复发率等情况.结果术后随访4～28(平均14.30±7.42)月.(1)复发率:A组为26.67%,B组为10.39%,C组为8.97%.A组较B、C两组的复发率显著性升高(P<0.05),但B、C两组间的复发率差异无显著性(P>0.05).(2)平均角膜创面愈合时间:C组为(2.30±0.31)天,B组为(6.15±0.40)天,两者差异有极显著性(P<0.01).结论翼状胬肉切除联合自体结膜瓣遮盖术或联合自体角膜缘干细胞移植术均能显著降低术后复发率后者还可显著加速翼状胬肉术后角膜创面愈合时间、减轻患者的自觉症状.
목적 비교삼충불동수술방식치료익상노육적료효.방법 대210례(230안)익상노육환자수궤분별채용단순수술절제(A조,공75안)、수술절제연합자체결막판차개(B조.공77안)、수술절제연합자체각막연간세포이식(C조,공78안).술후관찰각막창면적유합시간급익상노육적복발솔등정황.결과 술후수방4～28(평균14.30±7.42)월.(1)복발솔:A조위26.67%,B조위10.39%,C조위8.97%.A조교B、C량조적복발솔현저성승고(P<0.05),단B、C량조간적복발솔차이무현저성(P>0.05).(2)평균각막창면유합시간:C조위(2.30±0.31)천,B조위(6.15±0.40)천,량자차이유겁현저성(P<0.01).결론 익상노육절제연합자체결막판차개술혹연합자체각막연간세포이식술균능현저강저술후복발솔후자환가현저가속익상노육술후각막창면유합시간、감경환자적자각증상.
Objective Compared the clinical effect of simple excision of pterygium, limbal epithelium and conjunctiva autografting combined excision and combined excision of pterygium with stem cell transplantation of comeal limbus.Methods Two hundreds and ten cases(230 eyes) were divided into three groups according to operative method, the first group(75 eyes) were treated with simple excision, the secondgroup(77 eyes) were treated with limbal epithelium and conjunctiva autografting combined excision, the third group(78 eyes) were treated with combined excision of pterygium with stem cell transplantation of corneal limbus.Comea healing, limbal neovascular and tissue like pterygium hyperplasia were observed.Resulst: Following up was 4-28 months(averaged 14.30 ± 7.42). Recurrence rate was 26.67% in group A, 10.39% in group Band 8.97%in group C.The recurrence of epithelium in the group A was higher than those of the other two groups, But there were no significant differences between group B and group C .The average repair time of epithelium in the group C and group B were 2.30 ± 0.31 days and 6.15 ± 0.40 days ,the differences were remarkable in two groups(P< 0.05).Conclusions Limbal epithelium and conjunctiva autografting combined excision and combined excision of pterygium with stem cell transplantation of corneal limbus can reduce the recurrence significantly, the latter can lower the repair time of epithelium remarkably.