中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2011年
2期
125-128
,共4页
周文斌%白明%黄团新%胡贤主
週文斌%白明%黃糰新%鬍賢主
주문빈%백명%황단신%호현주
肺肿瘤%血管内皮生长因子类%内皮抑素类%吸烟
肺腫瘤%血管內皮生長因子類%內皮抑素類%吸煙
폐종류%혈관내피생장인자류%내피억소류%흡연
Lung neoplasmas%Vascular endothelial growth factors%Endostatins%Smoking
目的 探讨长期吸烟老年人血清血管内皮生长因子(vascular endothelial growth factor,VEGF)和内皮抑素(endostatin)水平的变化及其临床意义.方法 测定52例长期吸烟老年人血清VEGF和endostatin水平,其中伴肺癌组32例,不伴肺癌组20例,20例不吸烟健康老年人为正常对照组.结果 (1)伴肺癌组血清VEGF水平明显高于不伴肺癌组(t=13.681,P＜0.01)和对照组(t=9.372,P＜0.01).不伴肺癌组高于对照组(t=5.250,P＜0.05);(2)伴肺癌组血清endostatin水平明显高于对照组(t=5.332,P＜0.01),但与不伴肺癌组比较,差异无统计学意义(t=0.814,P＞0.05).不伴肺癌组与对照组比较,差异有统计学意义(t=3.700,P＜0.05);(3)伴肺癌组血清endostatin/VEGF比值明显低于不伴肺癌组(t=6.270,P＜0.01)和对照组(t=7.138,P＜0.01),但不伴肺癌组与对照组比较,差异无统计学意义(t=1.022,P＞0.05).结论 长期吸烟老年人应定期检测血清VEGF、endostatin水平及endostatin/VEGF比值,endostatin/VEGF比值可能是长期吸烟老年人早期诊断肺癌的指标之一.
目的 探討長期吸煙老年人血清血管內皮生長因子(vascular endothelial growth factor,VEGF)和內皮抑素(endostatin)水平的變化及其臨床意義.方法 測定52例長期吸煙老年人血清VEGF和endostatin水平,其中伴肺癌組32例,不伴肺癌組20例,20例不吸煙健康老年人為正常對照組.結果 (1)伴肺癌組血清VEGF水平明顯高于不伴肺癌組(t=13.681,P＜0.01)和對照組(t=9.372,P＜0.01).不伴肺癌組高于對照組(t=5.250,P＜0.05);(2)伴肺癌組血清endostatin水平明顯高于對照組(t=5.332,P＜0.01),但與不伴肺癌組比較,差異無統計學意義(t=0.814,P＞0.05).不伴肺癌組與對照組比較,差異有統計學意義(t=3.700,P＜0.05);(3)伴肺癌組血清endostatin/VEGF比值明顯低于不伴肺癌組(t=6.270,P＜0.01)和對照組(t=7.138,P＜0.01),但不伴肺癌組與對照組比較,差異無統計學意義(t=1.022,P＞0.05).結論 長期吸煙老年人應定期檢測血清VEGF、endostatin水平及endostatin/VEGF比值,endostatin/VEGF比值可能是長期吸煙老年人早期診斷肺癌的指標之一.
목적 탐토장기흡연노년인혈청혈관내피생장인자(vascular endothelial growth factor,VEGF)화내피억소(endostatin)수평적변화급기림상의의.방법 측정52례장기흡연노년인혈청VEGF화endostatin수평,기중반폐암조32례,불반폐암조20례,20례불흡연건강노년인위정상대조조.결과 (1)반폐암조혈청VEGF수평명현고우불반폐암조(t=13.681,P＜0.01)화대조조(t=9.372,P＜0.01).불반폐암조고우대조조(t=5.250,P＜0.05);(2)반폐암조혈청endostatin수평명현고우대조조(t=5.332,P＜0.01),단여불반폐암조비교,차이무통계학의의(t=0.814,P＞0.05).불반폐암조여대조조비교,차이유통계학의의(t=3.700,P＜0.05);(3)반폐암조혈청endostatin/VEGF비치명현저우불반폐암조(t=6.270,P＜0.01)화대조조(t=7.138,P＜0.01),단불반폐암조여대조조비교,차이무통계학의의(t=1.022,P＞0.05).결론 장기흡연노년인응정기검측혈청VEGF、endostatin수평급endostatin/VEGF비치,endostatin/VEGF비치가능시장기흡연노년인조기진단폐암적지표지일.
Objective To explore the changes and clinical significances of serum vascular endothelial growth factor (VEGF) and endostatin concentrations for early detection of lung cancer in elderly long-term smokers. Methods Serum VEGF and endostatin concentrations were determined in 52 elderly long-term smokers and 20 elderly non-smokers by enzyme linked immunoabsent assay (ELISA) or competitive enzyme immunoassay. The 52 elderly long-term smokers were divided into lung cancer group (n = 32) and non-lung cancer group (n = 20). Results The concentration of serum VEGF was markedly higher in lung cancer group [(15. 7±8. 0) ng/L] than in non-lung cancer group and normal control group (t= 13. 681, t= 9. 372, respectively, both P＜0. 01). And the level of serum VEGF was significantly higher in non-lung cancer group than in normal control group (t=5. 250, P＜0. 05). The level of serum endostatin was significantly higher in elderly long-term smokers with or without lung cancer than in normal control group (t=5. 332, t=3. 700, respectively, P＜0. 01 and P＜0.05). But there was no statistic difference between non-lung cancer group and lung cancer group (t = 0. 814, P＞ 0.05 ). Notably, the endostatin/VEGF ratio was lower in lung cancer group than in non-lung cancer group and normal control group (t= 6. 270, t= 7. 138, respectively, both P＜0.01), while there was no significant difference between non-lung cancer group and normal control group (t= 1. 022, P＞0.05). Conclusions These findings suggest that the periodic detection of serum VEGF and endostatin and endostatin/VEGF ratio, especially endostatin/VEGF ratio, is of clinical importance and can be used as an early diagnostic marker of lung cancer in elderly long-term smokers.
