CAJ | 학술논문

目的对比不同剂量的腺苷对巴马系小型猪左冠状动脉(冠脉)血流(CBF)及其储备(CFR)测量的影响.方法经导管于巴马系小型猪(n=10)左冠脉内团注不同剂量的腺苷(12、18、24和36μg),分别记录基础及充血状态下的心率、血压、基础CBF(rCBF)和最大充血时CBF(hCBF),以及CFR进行比较.结果冠脉内注射18μg腺苷可使血管最大扩张,18、24和36μg3种不同剂量下测得的心率、血压、rCBF及CFR差异无统计学意义.而12μg腺苷剂量测得的hCBF分别同24和36μg测得的hCBF差异有统计学意义(P＜0.05).结论腺苷18～24μg剂量可使巴马系小型猪左冠脉最大扩张,并能获得CBF及CFR的有效测量.
목적 대비불동제량적선감대파마계소형저좌관상동맥(관맥)혈류(CBF)급기저비(CFR)측량적영향.방법 경도관우파마계소형저(n=10)좌관맥내단주불동제량적선감(12、18、24화36μg),분별기록기출급충혈상태하적심솔、혈압、기출CBF(rCBF)화최대충혈시CBF(hCBF),이급CFR진행비교.결과 관맥내주사18μg선감가사혈관최대확장,18、24화36μg3충불동제량하측득적심솔、혈압、rCBF급CFR차이무통계학의의.이12μg선감제량측득적hCBF분별동24화36μg측득적hCBF차이유통계학의의(P＜0.05).결론 선감18～24μg제량가사파마계소형저좌관맥최대확장,병능획득CBF급CFR적유효측량.
Objective To compare the effects of different doses of adenosine(AD)on the left coronary blood flow(CBF)and left coronary flow reserve(CFR)in mini-swine.Methods By using Doppler flow wire and intracoronary ultrasound imaging catheter at the middle segment of LAD,coronary average peak flow velocity(APV)and lumen area were measured in 10 healthy mini-swines.CBF was calculated from the equation of 0.6 APV times 0.5 lumen area.Intracoronary bolus injection of different dose AD(12μg,18μg,24 μg and 36μg,separately)was used to induce maximal coronary hyperemic reaction.CFR was defined as the ratio of hyperemic CBF to resting CBF.Results Intracoronary bolus injection of 18μg AD level induced a maximal coronary vasodilation.Significant difference in the hyperemic CBF existed between 12 μg AD dose and 24μg or 36μg AD dose(P＜0.05).No significant difference in heart rate,blood pressure,rCBF and CFR was found among three different AD dose groups(18μg,24μg,and 36μg).Conclusion CBF and CFR in mini-swine can be effectively assessed by bolus injection of AD with the dose of(18～24)μg.