CAJ | 학술논문

观察不同剂量丙酸睾丸酮对MCF-7荷瘤裸鼠肿瘤生长的影响,并探讨其可能机制和临床意义.构建MCF-7荷瘤裸鼠,再用不同浓度的丙酸睾丸酮(50mg/kg,400mg/kg)及化疗药物(表阿霉素)进行干预,比较各组实验鼠肿瘤的生长情况,并用微粒子发光法检测裸鼠血清睾丸酮的含量,用流式细胞技术检测肿瘤中雄激素受体的表达.发现给予低剂量丙酸睾丸酮(50mg/kg)组的裸鼠肿瘤体积明显增大且明显高于对照组及化疗组(P=0.047,0.034),给予高剂量丙酸睾丸酮(400mg/kg)组裸鼠的肿瘤生长不一,三只肿瘤消褪,二只肿瘤生长.用药结束后400mg/kg丙酸睾丸酮组实验鼠血清睾丸酮水平明显升高,与50mg/kg组、化疗组及对照组相比差异有统计学意义(P=0.01 9,0.000,0.000).各组肿瘤中雄激素受体表达差异无统计学意义(P=0.177).低剂量丙酸睾丸酮可刺激MCF-7乳腺癌裸鼠肿瘤的生长,高剂量丙酸睾丸酮可能抑制MCF 7乳腺癌荷瘤裸鼠肿瘤的生长,但其作用并不明确,具体机制仍待进一步研究.雄激素对乳腺癌的治疗还需谨慎对待.
관찰불동제량병산고환동대MCF-7하류라서종류생장적영향,병탐토기가능궤제화림상의의.구건MCF-7하류라서,재용불동농도적병산고환동(50mg/kg,400mg/kg)급화료약물(표아매소)진행간예,비교각조실험서종류적생장정황,병용미입자발광법검측라서혈청고환동적함량,용류식세포기술검측종류중웅격소수체적표체.발현급여저제량병산고환동(50mg/kg)조적라서종류체적명현증대차명현고우대조조급화료조(P=0.047,0.034),급여고제량병산고환동(400mg/kg)조라서적종류생장불일,삼지종류소퇴,이지종류생장.용약결속후400mg/kg병산고환동조실험서혈청고환동수평명현승고,여50mg/kg조、화료조급대조조상비차이유통계학의의(P=0.01 9,0.000,0.000).각조종류중웅격소수체표체차이무통계학의의(P=0.177).저제량병산고환동가자격MCF-7유선암라서종류적생장,고제량병산고환동가능억제MCF 7유선암하류라서종류적생장,단기작용병불명학,구체궤제잉대진일보연구.웅격소대유선암적치료환수근신대대.