CAJ | 학술논문

目的构建理想的青春期病理性攻击动物模型.方法通过对青春期大鼠进行去奖赏性挫败实验与激惹刺激实验造模.采用旷野实验与糖水偏好实验、高架十字迷宫实验、嗅觉灵敏度实验评估其模型特异性.结果 ①病理性攻击组的总体攻击次数为[(101.17±2.85)次],与普通攻击组[(52.5±5.36)次]、正常对照组[(8.83±1.34)次]比较均存在显著性差异(P<0.01);②各组大鼠各行为指标与总分呈中.高度正相关(r=0.379～0.929);③病理性攻击组在危险部位攻击次数、屈服后继续攻击与攻击/威胁比与普通攻击组比较存在显著性差异(P<0.01);④病理性攻击组存在空间认知能力下降,但不表现抑郁、焦虑情绪和嗅觉障碍(P>0.05).而普通攻击组则存在明显抑郁情绪.结论各行为学指标满足青春期病理性攻击模型的评定标准,并且可以排除其他因素对模型特异性的干扰,提示该模型是较为理想的青春期病理性攻击模型.
목적 구건이상적청춘기병이성공격동물모형.방법 통과대청춘기대서진행거장상성좌패실험여격야자격실험조모.채용광야실험여당수편호실험、고가십자미궁실험、후각령민도실험평고기모형특이성.결과 ①병이성공격조적총체공격차수위[(101.17±2.85)차],여보통공격조[(52.5±5.36)차]、정상대조조[(8.83±1.34)차]비교균존재현저성차이(P<0.01);②각조대서각행위지표여총분정중.고도정상관(r=0.379～0.929);③병이성공격조재위험부위공격차수、굴복후계속공격여공격/위협비여보통공격조비교존재현저성차이(P<0.01);④병이성공격조존재공간인지능력하강,단불표현억욱、초필정서화후각장애(P>0.05).이보통공격조칙존재명현억욱정서.결론 각행위학지표만족청춘기병이성공격모형적평정표준,병차가이배제기타인소대모형특이성적간우,제시해모형시교위이상적청춘기병이성공격모형.
Objective To establish the preferable puberty pathological aggression animal model.Methods The experimental models were established towards puberty rats by frustration test of non-reward and instigation test.Rat models were tested for specificity using open-field test,saccharine test,elevated plus-maze(EPM)and olfactory sensibility.Results ①Compared with normal aggression(52.5±5.36)and control group(8.83±1.34)in total aggressive times,the pathological aggression group(101.17±2.85)increased significantly(P<0.01);②Some behavior items of each model group were moderately or hishly correlated to total score(r=0.379～0.929);③There was a significant difference between pathological aggression group and normal aggression group in the numbers of attack toward vulnerable-body regions,persistence attack after intruder displayed submissive and hish attack/threat ratios(P<0.01);④The pathological aggression group did not show depression,anxiety and olfactory disorder,except for space cognitive function(P>0.05).However,the normal aggression group displayed obvious depressive mood.Conclusion Each behavioral index matches the criteria of pathological aggression model.Meanwhile,it also excludes other factors of disturbing the specificity of the model.It suggests this model may be preferable puberty pathological aggression animal model.