国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2012年
5期
374-377
,共4页
IL-22%变应性疾病%气道%免疫
IL-22%變應性疾病%氣道%免疫
IL-22%변응성질병%기도%면역
Interleukin-22%Allergic disease%Airway%Immunity
IL-22是一种功能复杂的细胞因子,属于IL-10细胞因子家族成员,最初被命名为IL-10相关T细胞来源诱导因子,由179个氨基酸残基组成.体内的多种活化免疫细胞可以分泌IL-22,它的受体是由IL-22R1和IL-10R2构成的异源二聚体.IL-22在固有免疫和适应性免疫中均发挥重要作用.IL-22既有抗炎作用,也有促炎作用,参与炎症性疾病和多种免疫性疾病,例如银屑病、类风湿性关节炎和炎症性肠病.另外,IL-22在消化道的感染性疾病中起到抵抗微生物的作用.因而研究IL-22在气道变应性疾病中的作用很有意义.
IL-22是一種功能複雜的細胞因子,屬于IL-10細胞因子傢族成員,最初被命名為IL-10相關T細胞來源誘導因子,由179箇氨基痠殘基組成.體內的多種活化免疫細胞可以分泌IL-22,它的受體是由IL-22R1和IL-10R2構成的異源二聚體.IL-22在固有免疫和適應性免疫中均髮揮重要作用.IL-22既有抗炎作用,也有促炎作用,參與炎癥性疾病和多種免疫性疾病,例如銀屑病、類風濕性關節炎和炎癥性腸病.另外,IL-22在消化道的感染性疾病中起到牴抗微生物的作用.因而研究IL-22在氣道變應性疾病中的作用很有意義.
IL-22시일충공능복잡적세포인자,속우IL-10세포인자가족성원,최초피명명위IL-10상관T세포래원유도인자,유179개안기산잔기조성.체내적다충활화면역세포가이분비IL-22,타적수체시유IL-22R1화IL-10R2구성적이원이취체.IL-22재고유면역화괄응성면역중균발휘중요작용.IL-22기유항염작용,야유촉염작용,삼여염증성질병화다충면역성질병,례여은설병、류풍습성관절염화염증성장병.령외,IL-22재소화도적감염성질병중기도저항미생물적작용.인이연구IL-22재기도변응성질병중적작용흔유의의.
Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines and has complex functions.It was named IL-TIF for IL-10-related T cell-derived inducible factor.IL-22 is composed of 179 amino acid residues.A variety of activated immune cells are able to secrete IL-22 in vivo.Its receptors are a heterodimer composed of IL-22R1 and IL-10R2.IL-22 plays an important role in innate and adaptive immunity.In addition,and it has either anti-inflammatory or proinflammatory properties.It is also involved in inflammatory diseases and various immune diseases,such as psoriasis,rheumatoid arthritis and inflammatory bowel disease.Moreover,IL-22 plays a role of anti-microbial in the gastrointestinal infections.Recent studies has mainly focused on the role of IL-22 in allergic airway diseases.
