CAJ | 학술논문

目的观察替米沙坦对高血压患者颈总动脉内膜中层厚度的影响.方法选择104例轻、中度高血压病患者,随机分为替米沙坦组35例(服用替米沙坦80 mg/d)、雷米普利组35例(服用雷米普利5 mg/d)和对照组34例(使用其它降压药物).治疗过程中监测血压,入选患者开始时和治疗12个月后测定颈总动脉内膜中层厚度(CIMT).结果完成12个月治疗者共91例:替米沙坦组33例,雷米普利组28例,对照组30例.替米沙坦组和雷米普利组在有效降低血压同时,CIMT明显减低(均P<0.05),与对照组CIMT差异无统计学意义;雷米普利引起干咳需要停用药物者5例.结论替米沙坦能够有效降低血压并减低CIMT,雷米普利具有相似作用,但替米沙坦不良反应较少.
목적 관찰체미사탄대고혈압환자경총동맥내막중층후도적영향.방법 선택104례경、중도고혈압병환자,수궤분위체미사탄조35례(복용체미사탄80 mg/d)、뢰미보리조35례(복용뢰미보리5 mg/d)화대조조34례(사용기타강압약물).치료과정중감측혈압,입선환자개시시화치료12개월후측정경총동맥내막중층후도(CIMT).결과 완성12개월치료자공91례:체미사탄조33례,뢰미보리조28례,대조조30례.체미사탄조화뢰미보리조재유효강저혈압동시,CIMT명현감저(균P<0.05),여대조조CIMT차이무통계학의의;뢰미보리인기간해수요정용약물자5례.결론 체미사탄능구유효강저혈압병감저CIMT,뢰미보리구유상사작용,단체미사탄불량반응교소.
Objective To investigate inhibitory effect of Telmisartan on carotid arterial intima-media thickness in patients with essential hypertension. Methods 104 patients with mild or mid essential hypertension were randomly divided into three groups, which include telmisartan group( telmisartan 80 mg/d PO), ramipril group( ramipril 5 mg/d PO), and control group( other anti-hypertension agents). Blood pressure was monitored during treatment. Carotid arterial intima-media thickness(CIMT) were measured in all patients at beginning and patients who had the 12 months course. Results There were 91 patients who had the 12 months course,which include telmisartan group33 cases,ramipril group28 cases, and control 30 cases. The CIMT was significantly decreased in telmisartan group and ramipril group ( all P < 0. 05 ), and not changed in control while blood pressure fall effectively. In ramipril, group5 cases were ceased the course because of severe cough. Conclusion Both telmisartan and ramipril could decrease blood pressure and CIMT effectively, and there were less side effects in telmisartan group.